Literature DB >> 1680673

Identification of a somatostatin-14-generating propeptide converting enzyme as a member of the kex2/furin/PC family.

R B Mackin1, B D Noe, J Spiess.   

Abstract

A propeptide converting enzyme capable of producing somatostatin-14 has been identified and partially characterized from anglerfish pancreatic islets. Results from N-terminal protein sequence analysis indicate that this enzyme is a member of the kex2/furin/PC family. This observation provides strong corroborative evidence that the kex2/furin/PC protease family is involved in propeptide conversion. Comparison of the obtained protein sequence with the cDNA sequence of mammalian PC2 also suggests that the active enzyme is derived from a precursor by cleavage at a site containing four consecutive basic amino acids.

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Year:  1991        PMID： 1680673     DOI： 10.1210/endo-129-4-2263

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  6 in total

1.  Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells.

Authors:  F Jean; A Basak; N Rondeau; S Benjannet; G N Hendy; N G Seidah; M Chrétien; C Lazure
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857

2.  Heterologous processing of rat prosomatostatin to somatostatin-14 by PC2: requirement for secretory cell but not the secretion granule.

Authors:  A S Galanopoulou; N G Seidah; Y C Patel
Journal:  Biochem J       Date:  1995-10-01       Impact factor: 3.857

Review 3.  Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases.

Authors:  J C Hutton
Journal:  Diabetologia       Date:  1994-09       Impact factor: 10.122

4.  Conservation of the prohormone convertase gene family in metazoa: analysis of cDNAs encoding a PC3-like protein from hydra.

Authors:  S J Chan; A A Oliva; J LaMendola; A Grens; H Bode; D F Steiner
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205

5.  A C-terminal domain conserved in precursor processing proteases is required for intramolecular N-terminal maturation of pro-Kex2 protease.

Authors:  P Gluschankof; R S Fuller
Journal:  EMBO J       Date:  1994-05-15       Impact factor: 11.598

6.  Isolation and characterization of S. cerevisiae mutants defective in somatostatin expression: cloning and functional role of a yeast gene encoding an aspartyl protease in precursor processing at monobasic cleavage sites.

Authors:  Y Bourbonnais; J Ash; M Daigle; D Y Thomas
Journal:  EMBO J       Date:  1993-01       Impact factor: 11.598
  6 in total

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