BACKGROUND: Vitamin D receptor (VDR) mediates the effects of vitamin D. Our paper evaluates the FokI and BsmI VDR genotypes in 246 Caucasian (Italian from Lazio Region) T1DM patients compared with 246 Caucasian healthy controls, sharing age and gender and regional provenience with the patients. In addition, T1DM patients without complications were compared with those carrying three complications. METHODS: Genotyping has been obtained by RFLP-PCR technique. RESULTS: A slight significant association of T1DM with FokI homozygous "f" genotype was observed. No association was observed with the presence of multiple complications by a multivariate analysis. CONCLUSION: T1DM patients showed slightly increased prevalence of "ff" VDR genotype.
BACKGROUND:Vitamin D receptor (VDR) mediates the effects of vitamin D. Our paper evaluates the FokI and BsmI VDR genotypes in 246 Caucasian (Italian from Lazio Region) T1DM patients compared with 246 Caucasian healthy controls, sharing age and gender and regional provenience with the patients. In addition, T1DM patients without complications were compared with those carrying three complications. METHODS: Genotyping has been obtained by RFLP-PCR technique. RESULTS: A slight significant association of T1DM with FokI homozygous "f" genotype was observed. No association was observed with the presence of multiple complications by a multivariate analysis. CONCLUSION: T1DM patients showed slightly increased prevalence of "ff" VDR genotype.
Authors: Jose C E Serrano; David De Lorenzo; Anna Cassanye; Meritxell Martín-Gari; Alberto Espinel; Marco Antonio Delgado; Reinald Pamplona; Manuel Portero-Otin Journal: Genes Nutr Date: 2013-09-25 Impact factor: 5.523
Authors: B Frederiksen; E Liu; J Romanos; A K Steck; X Yin; M Kroehl; T E Fingerlin; H Erlich; G S Eisenbarth; M Rewers; J M Norris Journal: J Steroid Biochem Mol Biol Date: 2012-09-07 Impact factor: 4.292