Literature DB >> 16806109

Ameliorative effect of pioglitazone on seizure responses in genetically epilepsy-susceptible EL mice.

Kazumasa Okada1, Uki Yamashita, Sadatoshi Tsuji.   

Abstract

Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, delayed the development of seizure responses and mildly shortened the duration of convulsion of genetically epileptic EL mice. mRNA levels of IL-1beta, IL-6 and TNF-alpha before seizure and mRNA levels of IL-6 and TNF-alpha after seizure were decreased in the brains of the mice with pioglitazone. These results suggest that pioglitazone may have ameliorative effects on epileptic seizure responses partly through the reduction of inflammatory responses in the brain.

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Year:  2006        PMID： 16806109     DOI： 10.1016/j.brainres.2006.04.108

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

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Review 2.  The ongoing pursuit of neuroprotective therapies in Parkinson disease.

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3.  Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease.

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4.  Regulation of brain PPARgamma2 contributes to ketogenic diet anti-seizure efficacy.

Authors:  Timothy A Simeone; Stephanie A Matthews; Kaeli K Samson; Kristina A Simeone
Journal:  Exp Neurol       Date:  2016-08-12       Impact factor: 5.330

5.  The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys.

Authors:  Christine R Swanson; Valerie Joers; Viktoriya Bondarenko; Kevin Brunner; Heather A Simmons; Toni E Ziegler; Joseph W Kemnitz; Jeffrey A Johnson; Marina E Emborg
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6.  Effect of pioglitazone on excitotoxic neuronal damage in the mouse hippocampus.

Authors:  Choong Hyun Lee; Min-Hee Yi; Dong Jin Chae; Enji Zhang; Sang-Ha Oh; Dong Woon Kim
Journal:  Biomol Ther (Seoul)       Date:  2015-05-01       Impact factor: 4.634

7.  Effects of peroxisome proliferator activated receptors (PPAR)-γ and -α agonists on cochlear protection from oxidative stress.

Authors:  Marijana Sekulic-Jablanovic; Vesna Petkovic; Matthew B Wright; Krystsina Kucharava; Nathan Huerzeler; Soledad Levano; Yves Brand; Katharina Leitmeyer; Andrea Glutz; Alexander Bausch; Daniel Bodmer
Journal:  PLoS One       Date:  2017-11-28       Impact factor: 3.240

8.  Anticonvulsant and ameliorative effects of pioglitazone on cognitive deficits, inflammation and apoptosis in the hippocampus of rat pups exposed to febrile seizure.

Authors:  Hussein Allawi Hussein; Ali Moghimi; Ali Roohbakhsh
Journal:  Iran J Basic Med Sci       Date:  2019-03       Impact factor: 2.699
  8 in total

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