BACKGROUND: A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). METHODS: In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers. RESULTS: We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN. CONCLUSIONS: These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes.
BACKGROUND: A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). METHODS: In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers. RESULTS: We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN. CONCLUSIONS: These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes.
Authors: Stephanie J Klenotich; Mariel P Seiglie; Matthew S McMurray; Jamie D Roitman; Daniel Le Grange; Priya Dugad; Stephanie C Dulawa Journal: Neuropsychopharmacology Date: 2012-03-07 Impact factor: 7.853
Authors: Joseph L Roberts; Rebecca H Buckley; Biao Luo; Jianming Pei; Alla Lapidus; Suraj Peri; Qiong Wei; Jinwook Shin; Roberta E Parrott; Roland L Dunbrack; Joseph R Testa; Xiao-Ping Zhong; David L Wiest Journal: Proc Natl Acad Sci U S A Date: 2012-06-11 Impact factor: 11.205
Authors: Andrea Poyastro Pinheiro; Cynthia M Bulik; Laura M Thornton; Patrick F Sullivan; Tammy L Root; Cinnamon S Bloss; Wade H Berrettini; Nicholas J Schork; Walter H Kaye; Andrew W Bergen; Pierre Magistretti; Harry Brandt; Steve Crawford; Scott Crow; Manfred M Fichter; David Goldman; Katherine A Halmi; Craig Johnson; Allan S Kaplan; Pamela K Keel; Kelly L Klump; Maria La Via; James E Mitchell; Michael Strober; Alessandro Rotondo; Janet Treasure; D Blake Woodside Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2010-07 Impact factor: 3.568