| Literature DB >> 16806053 |
Barbara Cannon1, Irina G Shabalina, Tatiana V Kramarova, Natasa Petrovic, Jan Nedergaard.
Abstract
A physiological function of the original uncoupling protein, UCP1, is well established: UCP1 is the molecular background for nonshivering thermogenesis. The functions of the "novel" UCPs, UCP2 and UCP3, are still not established. Recent discussions imply that all UCPs may play a role in protection against reactive oxygen species (ROS). Here we examine critically the evidence that UCP1, UCP2 and UCP3 are stimulated by ROS (superoxide) or ROS products (4-hydroxy-2-nonenal), and that the UCPs actually diminish oxidative damage. We conclude that, concerning UCP1, it is unlikely that it has such a role; concerning UCP2/UCP3, most evidence for physiologically significant roles in this respect is still circumstantial.Entities:
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Year: 2006 PMID： 16806053 DOI： 10.1016/j.bbabio.2006.05.016
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002