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Literature DB >> 16805666

Cellular responses to DNA damage: one signal, multiple choices.

Abstract

DNA double-strand breaks (DSBs) produce a number of cellular responses, some mutually exclusive. Depending on where on the chromosome it occurs, a DSB may become preserved inside a telomere or eliminated by repair. A cell may arrest division via checkpoint activation to fix DSBs or commit suicide by apoptosis. What determines the outcome: to bury, fix, or succumb to DNA DSBs? With this question in mind, we review recent data on cellular responses to DSBs.

Entities: Chemical

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Year: 2006 PMID： 16805666 DOI： 10.1146/annurev.genet.40.110405.090428

Source DB: PubMed Journal: Annu Rev Genet ISSN： 0066-4197 Impact factor: 16.830

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Cited

86 in total

1. RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo.

Authors: Jiaxue Wu; Chao Liu; Junjie Chen; Xiaochun Yu
Journal: J Biol Chem Date: 2012-04-25 Impact factor: 5.157

Review 9. Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways.

Authors: Martin A Cohn; Alan D D'Andrea
Journal: Mol Cell Date: 2008-11-07 Impact factor: 17.970

10. Effects of corexit oil dispersants and the WAF of dispersed oil on DNA damage and repair in cultured human bronchial airway cells, BEAS-2B.

Authors: Danielle Major; Rebecca S Derbes; He Wang; Astrid M Roy-Engel
Journal: Gene Rep Date: 2016-02-11

Cellular responses to DNA damage: one signal, multiple choices.

1. RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo.

2. Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.

Review 3. Cell cycle regulation of DNA replication.

Review 4. DNA-damage repair; the good, the bad, and the ugly.

5. Enterococcus faecalis induces aneuploidy and tetraploidy in colonic epithelial cells through a bystander effect.

6. PTIP regulates 53BP1 and SMC1 at the DNA damage sites.

7. Baculoviruses modulate a proapoptotic DNA damage response to promote virus multiplication.

8. Cre recombinase induces DNA damage and tetraploidy in the absence of loxP sites.

Review 9. Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways.

10. Effects of corexit oil dispersants and the WAF of dispersed oil on DNA damage and repair in cultured human bronchial airway cells, BEAS-2B.