Literature DB >> 1680545

Transglutaminase activity in human colorectal carcinomas of differing metastatic potential.

K A Zirvi1, J P Keogh, A Slomiany, B L Slomiany.   

Abstract

Transglutaminase (TGA) activity in four human colorectal carcinoma cell lines of differing metastatic potential, and the effects of mild proteolysis on this activity, was investigated. Rank order of metastatic activity measured in nude mice (intrasplenic injection) was found to be LS174T greater than SW620 greater than WiDr greater than SW480. Rank orders of TGA activity were SW480 greater than WiDr greater than SW620 greater than LS174T. Proteolysis of cell lysates increased LS174T TGA activity 42-fold, SW620 2-fold without affecting WiDr or SW480 activity. Hence a negative association exists between metastatic potential and TGA activity in human colorectal carcinoma cells. Furthermore, a positive association exists between proteolytic activation of TGA and metastatic potential.

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Year:  1991        PMID： 1680545     DOI： 10.1016/0304-3835(91)90052-j

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  8 in total

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4.  Serum biomarker panels for the detection of pancreatic cancer.

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7.  The expression of genes contributing to pancreatic adenocarcinoma progression is influenced by the respective environment.

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Journal:  Genes Cancer       Date:  2018-03

8.  Distinct shed microvesicle and exosome microRNA signatures reveal diagnostic markers for colorectal cancer.

Authors:  Maoshan Chen; Rong Xu; Alin Rai; Wittaya Suwakulsiri; Keiichi Izumikawa; Hideaki Ishikawa; David W Greening; Nobuhiro Takahashi; Richard J Simpson
Journal:  PLoS One       Date:  2019-01-04       Impact factor: 3.240
  8 in total

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