| Literature DB >> 16803988 |
Sunil C Kaul1, Kamrul Hasan, Renu Wadhwa.
Abstract
CARF was first cloned as a novel binding partner of ARF from a yeast-interactive screen. CARF and ARF colocalize in the perinucleolar region and have a collaborative function. In the nucleoplasm, CARF interacts with p53 and enhances its function. We demonstrate that p53 downregulates CARF in a negative feedback regulatory loop and may also involve p53 antagonist HDM2.Entities:
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Year: 2006 PMID： 16803988 DOI： 10.1196/annals.1354.026
Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691