Literature DB >> 16803577

Serum levels of angiogenic factors indicate a pro-angiogenic state in adults with sickle cell disease.

Ashley J Duits1, Tati Rodriguez, John-John B Schnog.   

Abstract

Hypoxia-induced angiogenesis may play an important role in the pathophysiology of sickle cell disease (SCD). Serum levels of angiopoietin (Ang)-1, Ang-2, vascular endothelial growth factor, placenta growth factor (PlGF), soluble tunica intima endothelial kinase 2 (sTIE2), erythropoietin (EPO) and endothelial activation markers (soluble vascular adhesion molecule-1, soluble intercellular adhesion molecule-1) were determined in controls, HbSS (n = 35) and HbSC (n = 23) patients. In the asymptomatic phase, serum Ang-2 (P < 0.001), EPO (P < 0.001) and sTIE2 (P = 0.03) were elevated in patients. During painful crises, increased Ang-2 (P < 0.001) and PlGF (P = 0.04) occurred in HbSS and Ang-2 (P = 0.05) in HbSC patients. These results indicate a pro-angiogenic state in SCD, mainly because of elevated Ang-2 levels.

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Year:  2006        PMID： 16803577     DOI： 10.1111/j.1365-2141.2006.06103.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  15 in total

1.  Erythropoietin-mediated expression of placenta growth factor is regulated via activation of hypoxia-inducible factor-1α and post-transcriptionally by miR-214 in sickle cell disease.

Authors:  Caryn S Gonsalves; Chen Li; Marthe-Sandrine Eiymo Mwa Mpollo; Vinod Pullarkat; Punam Malik; Stanley M Tahara; Vijay K Kalra
Journal:  Biochem J       Date:  2015-04-16       Impact factor: 3.857

2.  Morphine promotes neovascularizing retinopathy in sickle transgeneic mice.

Authors:  Kalpna Gupta; Chunsheng Chen; Gerard A Lutty; Robert P Hebbel
Journal:  Blood Adv       Date:  2019-04-09

Review 3.  Placental growth factor: What hematologists need to know.

Authors:  Laura F Newell; Shernan G Holtan
Journal:  Blood Rev       Date:  2016-08-27       Impact factor: 8.250

4.  Key endothelial cell angiogenic mechanisms are stimulated by the circulating milieu in sickle cell disease and attenuated by hydroxyurea.

Authors:  Flavia C M Lopes; Fabiola Traina; Camila B Almeida; Flavia C Leonardo; Carla F Franco-Penteado; Vanessa T Garrido; Marina P Colella; Raquel Soares; Sara T Olalla-Saad; Fernando F Costa; Nicola Conran
Journal:  Haematologica       Date:  2015-03-13       Impact factor: 9.941

5.  Efficient Quantitative Analysis of Carboxyalkylpyrrole Ethanolamine Phospholipids: Elevated Levels in Sickle Cell Disease Blood.

Authors:  Junhong Guo; Hua Wang; Borys Hrinczenko; Robert G Salomon
Journal:  Chem Res Toxicol       Date:  2016-06-24       Impact factor: 3.739

6.  Placental growth factor attenuates suppression of erythroid colony formation by interferon.

Authors:  Gail Dallalio; Robert T Means
Journal:  Transl Res       Date:  2008-10-29       Impact factor: 7.012

7.  Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor.

Authors:  Xunde Wang; Laurel Mendelsohn; Heather Rogers; Susan Leitman; Nalini Raghavachari; Yanqin Yang; Yu Ying Yau; Michael Tallack; Andrew Perkins; James G Taylor; Constance Tom Noguchi; Gregory J Kato
Journal:  Blood       Date:  2014-06-10       Impact factor: 22.113

8.  Inflammation in sickle cell disease.

Authors:  Nicola Conran; John D Belcher
Journal:  Clin Hemorheol Microcirc       Date:  2018       Impact factor: 2.375

9.  Placenta growth factor in sickle cell disease: association with hemolysis and inflammation.

Authors:  Julia E Brittain; Ben Hulkower; Susan K Jones; Dell Strayhorn; Laura De Castro; Marilyn J Telen; Eugene P Orringer; Alan Hinderliter; Kenneth I Ataga
Journal:  Blood       Date:  2009-12-29       Impact factor: 22.113

10.  Elevated circulating angiogenic progenitors and white blood cells are associated with hypoxia-inducible angiogenic growth factors in children with sickle cell disease.

Authors:  Solomon F Ofori-Acquah; Iris D Buchanan; Ifeyinwa Osunkwo; Jerry Manlove-Simmons; Feyisayo Lawal; Alexander Quarshie; Arshed A Quyyumi; Gary H Gibbons; Beatrice E Gee
Journal:  Anemia       Date:  2012-05-23
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