Literature DB >> 16803568

Validation of the European Prognostic Index for younger adult patients with acute myeloid leukaemia in first relapse.

Francis Giles1, Srdan Verstovsek, Guillermo Garcia-Manero, Deborah Thomas, Farhad Ravandi, William Wierda, Alessandra Ferrajoli, Steve Kornblau, Elias Jabbour, Jianqin Shan, Susan O'brien, Maher Albitar, Hagop Kantarjian.   

Abstract

In order to validate the European Prognostic Index (EPI) for patients <or=60 years with acute myeloid leukaemia in first relapse, a cohort of 599 such patients, treated between 1980 and 2004 at the MD Anderson Cancer Center, were assessed using this prognostic index. Three risk groups were defined: favourable, 76 patients (13%) [Overall survival (OS), 64% at 1 year, 22% at 5 years]; intermediate, 137 patients (23%) (OS, 38% at 1 year, 12% at 5 years); and poor, 386 patients (64%) (OS, 17% at 1 year 6% at 5 years). The EPI is reproducible and useful.

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Year:  2006        PMID: 16803568     DOI: 10.1111/j.1365-2141.2006.06106.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN: 0007-1048            Impact factor:   6.998


  6 in total

1.  Elacytarabine has single-agent activity in patients with advanced acute myeloid leukaemia.

Authors:  Susan O'Brien; David A Rizzieri; Norbert Vey; Farhad Ravandi; Utz O Krug; Mikkael A Sekeres; Mike Dennis; Adriano Venditti; Donald A Berry; Tove Flem Jacobsen; Karin Staudacher; Trygve Bergeland; Francis J Giles
Journal:  Br J Haematol       Date:  2012-06-15       Impact factor: 6.998

Review 2.  Clinical potential of elacytarabine in patients with acute myeloid leukemia.

Authors:  Lindsay A M Rein; David A Rizzieri
Journal:  Ther Adv Hematol       Date:  2014-12

Review 3.  Reporting performance of prognostic models in cancer: a review.

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4.  Salvage therapy for relapsed or refractory acute myeloid leukemia.

Authors:  James K Mangan; Selina M Luger
Journal:  Ther Adv Hematol       Date:  2011-04

5.  How I treat relapsed or refractory AML.

Authors:  Susan DeWolf; Martin S Tallman
Journal:  Blood       Date:  2020-08-27       Impact factor: 22.113

6.  Ara-C, Idarubicine and Gentuzumab Ozogamicin (AIM) as Salvage Treatment in Advanced Acute Myeloid Leukemia Patients.

Authors:  Saveria Capria; Silvia Maria Trisolini; Clara Minotti; Caterina Stefanizzi; Luisa Cardarelli; Claudio Cartoni; Daniela Diverio; Maria Stefania De Propris; Marco Mancini; Alessandra Micozzi; Robin Foà; Giovanna Meloni
Journal:  Mediterr J Hematol Infect Dis       Date:  2012-11-06       Impact factor: 2.576

  6 in total

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