Literature DB >> 1680323

HIV-1 reproduction is inhibited by peptides derived frm the N- and C-termini of HIV-1 protease.

H J Schramm1, H Nakashima, W Schramm, H Wakayama, N Yamamoto.   

Abstract

Two octapeptides derived from the sequence of the N- and C-termini of HIV-1 protease were tested for their ability to inhibit HIV-1 reproduction. Weak inhibitory activity was found with each of the two peptides. It is assumed that HIV-1 protease is the target of the inhibitory action. In spite of the moderate inhibitory activity the results are encouraging since they may be improved by various means.

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Year:  1991        PMID： 1680323     DOI： 10.1016/0006-291x(91)91895-j

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

1.  Design of dimerization inhibitors of HIV-1 aspartic proteinase: a computer-based combinatorial approach.

Authors:  A Caflisch; H J Schramm; M Karplus
Journal:  J Comput Aided Mol Des       Date:  2000-02       Impact factor: 3.686

2.  Inhibition of the HIV-1 and HIV-2 proteases by a monoclonal antibody.

Authors:  J Lescar; J Brynda; P Rezacova; R Stouracova; M M Riottot; V Chitarra; M Fabry; M Horejsi; J Sedlacek; G A Bentley
Journal:  Protein Sci       Date:  1999-12       Impact factor: 6.725

3.  Genetic selection for dissociative inhibitors of designated protein-protein interactions.

Authors:  S H Park; R T Raines
Journal:  Nat Biotechnol       Date:  2000-08       Impact factor: 54.908

4.  Model-free analysis for large proteins at high magnetic field strengths.

Authors:  Shou-Lin Chang; Andrew P Hinck; Rieko Ishima
Journal:  J Biomol NMR       Date:  2007-06-26       Impact factor: 2.835

5.  Importance of the N terminus of rous sarcoma virus protease for structure and enzymatic function.

Authors:  G W Schatz; J Reinking; J Zippin; L K Nicholson; V M Vogt
Journal:  J Virol       Date:  2001-05       Impact factor: 5.103

6.  Proteolytic activity of novel human immunodeficiency virus type 1 proteinase proteins from a precursor with a blocking mutation at the N terminus of the PR domain.

Authors:  G Zybarth; H G Kräusslich; K Partin; C Carter
Journal:  J Virol       Date:  1994-01       Impact factor: 5.103

7.  Novel macromolecular inhibitors of human immunodeficiency virus-1 protease.

Authors:  Gabriella Miklóssy; József Tözsér; János Kádas; Rieko Ishima; John M Louis; Péter Bagossi
Journal:  Protein Eng Des Sel       Date:  2008-05-13       Impact factor: 1.650

8.  Targeting human immunodeficiency virus type 1 assembly, maturation and budding.

Authors:  Johanna Wapling; Seema Srivastava; Miranda Shehu-Xhilaga; Gilda Tachedjian
Journal:  Drug Target Insights       Date:  2007-07-20

Review 9.  Targeting the Dimerization of the Main Protease of Coronaviruses: A Potential Broad-Spectrum Therapeutic Strategy.

Authors:  Bhupesh Goyal; Deepti Goyal
Journal:  ACS Comb Sci       Date:  2020-05-27       Impact factor: 3.784

10.  The N-terminal octapeptide acts as a dimerization inhibitor of SARS coronavirus 3C-like proteinase.

Authors:  Ping Wei; Keqiang Fan; Hao Chen; Liang Ma; Changkang Huang; Lei Tan; Dong Xi; Chunmei Li; Ying Liu; Aoneng Cao; Luhua Lai
Journal:  Biochem Biophys Res Commun       Date:  2005-11-28       Impact factor: 3.575
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