Literature DB >> 16802294

Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study.

Hilary A Archer1, Paul Edison, David J Brooks, Jo Barnes, Chris Frost, Tom Yeatman, Nick C Fox, Martin N Rossor.   

Abstract

To determine the relationship between cerebral amyloid plaque load and rates of cerebral atrophy in Alzheimer's disease. (11)C-PIB((11)C-6-OH benzothiazole)PET (positron emission tomography) findings were correlated with volumetric magnetic resonance imaging (MRI) measurements in nine subjects with mild to moderate AD. Analysis revealed a positive correlation between rates of whole brain atrophy and whole brain (p = 0.019) and regional (11)C-PIB uptake. This provides support for the central role of amyloid deposition in the pathogenesis of AD.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16802294     DOI： 10.1002/ana.20889

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  72 in total

Review 1.  Positron emission tomography imaging in neurological disorders.

Authors:  Marios Politis; Paola Piccini
Journal:  J Neurol       Date:  2012-09       Impact factor: 4.849

Review 2.  Molecular brain imaging in the multimodality era.

Authors:  Julie C Price
Journal:  J Cereb Blood Flow Metab       Date:  2012-03-21       Impact factor: 6.200

3.  Safety of disclosing amyloid status in cognitively normal older adults.

Authors:  Jeffrey M Burns; David K Johnson; Edward P Liebmann; Rebecca J Bothwell; Jill K Morris; Eric D Vidoni
Journal:  Alzheimers Dement       Date:  2017-03-03       Impact factor: 21.566

4.  Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly.

Authors:  Anne M Fagan; Denise Head; Aarti R Shah; Daniel Marcus; Mark Mintun; John C Morris; David M Holtzman
Journal:  Ann Neurol       Date:  2009-02       Impact factor: 10.422

Review 5.  The ART of loss: Abeta imaging in the evaluation of Alzheimer's disease and other dementias.

Authors:  Victor L Villemagne; Michelle T Fodero-Tavoletti; Kerryn E Pike; Roberto Cappai; Colin L Masters; Christopher C Rowe
Journal:  Mol Neurobiol       Date:  2008-08-09       Impact factor: 5.590

6.  Association of gray matter atrophy with age, β-amyloid, and cognition in aging.

Authors:  Hwamee Oh; Cindee Madison; Sylvia Villeneuve; Candace Markley; William J Jagust
Journal:  Cereb Cortex       Date:  2013-02-06       Impact factor: 5.357

7.  Aβ-related hyperactivation in frontoparietal control regions in cognitively normal elderly.

Authors:  Hwamee Oh; Jason Steffener; Qolamreza R Razlighi; Christian Habeck; Dan Liu; Yunglin Gazes; Sarah Janicki; Yaakov Stern
Journal:  Neurobiol Aging       Date:  2015-08-24       Impact factor: 4.673

Review 8.  Amyloid imaging of Alzheimer's disease using Pittsburgh Compound B.

Authors:  Keith A Johnson
Journal:  Curr Neurol Neurosci Rep       Date:  2006-11       Impact factor: 5.081

Review 9.  Amyloid Imaging: Poised for Integration into Medical Practice.

Authors:  Keshav Anand; Marwan Sabbagh
Journal:  Neurotherapeutics       Date:  2017-01       Impact factor: 7.620

Review 10.  Using Pittsburgh Compound B for in vivo PET imaging of fibrillar amyloid-beta.

Authors:  Ann D Cohen; Gil D Rabinovici; Chester A Mathis; William J Jagust; William E Klunk; Milos D Ikonomovic
Journal:  Adv Pharmacol       Date:  2012
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.