| Literature DB >> 16801663 |
R Fernández-Santiago1, M Sharma, J C Mueller, H Gohlke, T Illig, J Anneser, C Münch, A Ludolph, C Kamm, T Gasser.
Abstract
Individuals homozygous for haplotypes -2578-A/-1154-A/-634-G or -2578-A/-1154-G/-634-G in the promoter/5'UTR of the VEGF gene have a 1.8-fold increased risk of ALS in several European populations. We did not observe any significant association with single markers, or haplotype pairs, in a German sample of 580 sporadic ALS patients and 628 controls. However, the promoter SNP-1154 (rs1570360) was associated with affection status in women (p = 0.036), suggesting that the VEGF effect may be dependent on the sex ratio of the sample.Entities:
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Year: 2006 PMID： 16801663 DOI： 10.1212/01.wnl.0000219756.71928.25
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910