OBJECTIVE: To evaluate the cognitive and behavioral effects of bilateral subthalamic nucleus (STN) stimulation in patients with Parkinson disease (PD). METHODS: The authors included 103 patients; 99 patients were evaluated 6 months after surgery. A control group of 39 patients with PD was formed and 36 patients were evaluated 6 months later. At baseline and at follow-up we administered neuropsychological tests of language, memory, visuospatial function, mental speed, and executive functions. A depression rating scale, a quality of life scale, self and proxy ratings of memory and dysexecutive symptoms, and a neuropsychiatric interview were also administered. RESULTS: Six months after surgery, the STN group showed a larger decline than the control group on measures of verbal fluency, color naming, selective attention, and verbal memory. Moreover, the STN group showed a decrease in positive affect, and an increase in emotional lability and cognitive complaints. On the other hand, the STN group showed an increase in quality of life and a slight decrease in depressive symptoms. Nine percent of the STN patients had psychiatric complications (vs 3% of controls). CONCLUSIONS: Bilateral subthalamic nucleus stimulation has an adverse effect on executive functions with implications for daily life of the patients and their relatives.
OBJECTIVE: To evaluate the cognitive and behavioral effects of bilateral subthalamic nucleus (STN) stimulation in patients with Parkinson disease (PD). METHODS: The authors included 103 patients; 99 patients were evaluated 6 months after surgery. A control group of 39 patients with PD was formed and 36 patients were evaluated 6 months later. At baseline and at follow-up we administered neuropsychological tests of language, memory, visuospatial function, mental speed, and executive functions. A depression rating scale, a quality of life scale, self and proxy ratings of memory and dysexecutive symptoms, and a neuropsychiatric interview were also administered. RESULTS: Six months after surgery, the STN group showed a larger decline than the control group on measures of verbal fluency, color naming, selective attention, and verbal memory. Moreover, the STN group showed a decrease in positive affect, and an increase in emotional lability and cognitive complaints. On the other hand, the STN group showed an increase in quality of life and a slight decrease in depressive symptoms. Nine percent of the STN patients had psychiatric complications (vs 3% of controls). CONCLUSIONS: Bilateral subthalamic nucleus stimulation has an adverse effect on executive functions with implications for daily life of the patients and their relatives.
Authors: Lucy Gee; Heather Smith; Priscilla De La Cruz; Joannalee Campbell; Chris Fama; Jessica Haller; Adolfo Ramirez-Zamora; Jennifer Durphy; Era Hanspal; Eric Molho; Anne Barba; Damian Shin; Julie G Pilitsis Journal: Stereotact Funct Neurosurg Date: 2015-06-10 Impact factor: 1.875
Authors: Sarah A Eisenstein; Jonathan M Koller; Kathleen D Black; Meghan C Campbell; Heather M Lugar; Mwiza Ushe; Samer D Tabbal; Morvarid Karimi; Tamara Hershey; Joel S Perlmutter; Kevin J Black Journal: Ann Neurol Date: 2014-07-02 Impact factor: 10.422
Authors: Laura B Zahodne; Michael S Okun; Kelly D Foote; Hubert H Fernandez; Ramon L Rodriguez; Lindsey Kirsch-Darrow; Dawn Bowers Journal: Clin Neuropsychol Date: 2008-09-23 Impact factor: 3.535