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Literature DB >> 16801445

Effect of cell culture conditions on the anticytomegalovirus activity of maribavir.

Sunwen Chou¹, Laura C Van Wechel, Gail I Marousek.

Abstract

The cytomegalovirus UL97 kinase inhibitor maribavir suppressed viral growth more effectively in lung fibroblasts than in skin fibroblasts, and some cellular kinase inhibitors enhanced its antiviral activity. These effects influence the phenotypic assay of drug susceptibility and suggest the possibility of therapeutically useful combinations of maribavir and cellular kinase inhibitors.

Entities: Chemical

Mesh：

Substances：

Year: 2006 PMID： 16801445 PMCID： PMC1489798 DOI： 10.1128/AAC.00207-06

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

10 in total

1. Inhibition of cytomegalovirus in vitro and in vivo by the experimental immunosuppressive agent leflunomide.

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2. Phenotyping of cytomegalovirus drug resistance mutations by using recombinant viruses incorporating a reporter gene.

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Review 3. The pleiotropic effects of mTor inhibitors.

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4. Inhibition of cellular Cdk2 activity blocks human cytomegalovirus replication.

Authors: W A Bresnahan; I Boldogh; P Chi; E A Thompson; T Albrecht
Journal: Virology Date: 1997-05-12 Impact factor: 3.616

5. Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling.

Authors: R A Johnson; X Wang; X L Ma; S M Huong; E S Huang
Journal: J Virol Date: 2001-07 Impact factor: 5.103

6. Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action.

Authors: Karen K Biron; Robert J Harvey; Stanley C Chamberlain; Steven S Good; Albert A Smith; Michelle G Davis; Christine L Talarico; Wayne H Miller; Robert Ferris; Ronna E Dornsife; Sylvia C Stanat; John C Drach; Leroy B Townsend; George W Koszalka
Journal: Antimicrob Agents Chemother Date: 2002-08 Impact factor: 5.191

7. Cyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production.

Authors: Veronica Sanchez; Anita K McElroy; Judy Yen; Sama Tamrakar; Charles L Clark; Rachel A Schwartz; Deborah H Spector
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8. In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses.

Authors: Stephanie L Williams; Caroll B Hartline; Nicole L Kushner; Emma A Harden; Deborah J Bidanset; John C Drach; Leroy B Townsend; Mark R Underwood; Karen K Biron; Earl R Kern
Journal: Antimicrob Agents Chemother Date: 2003-07 Impact factor: 5.191

9. Phase I dose escalation trial evaluating the pharmacokinetics, anti-human cytomegalovirus (HCMV) activity, and safety of 1263W94 in human immunodeficiency virus-infected men with asymptomatic HCMV shedding.

Authors: Jacob P Lalezari; Judith A Aberg; Laurene H Wang; Mary Beth Wire; Richard Miner; Wendy Snowden; Christine L Talarico; Shuching Shaw; Mark A Jacobson; W Lawrence Drew
Journal: Antimicrob Agents Chemother Date: 2002-09 Impact factor: 5.191

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10 in total

33 in total

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Authors: Sunwen Chou
Journal: Antimicrob Agents Chemother Date: 2008-11-03 Impact factor: 5.191

3. Cytomegalovirus UL97 kinase catalytic domain mutations that confer multidrug resistance.

Authors: Sunwen Chou; Ronald J Ercolani; Gail Marousek; Terry L Bowlin
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Review 4. Current and potential treatments for ubiquitous but neglected herpesvirus infections.

Authors: Jonathan E Gable; Timothy M Acker; Charles S Craik
Journal: Chem Rev Date: 2014-10-02 Impact factor: 60.622

5. A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations.

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Journal: Antimicrob Agents Chemother Date: 2015-01-26 Impact factor: 5.191

6. Differential properties of cytomegalovirus pUL97 kinase isoforms affect viral replication and maribavir susceptibility.

Authors: Rike Webel; Morgan Hakki; Mark N Prichard; William D Rawlinson; Manfred Marschall; Sunwen Chou
Journal: J Virol Date: 2014-02-12 Impact factor: 5.103

7. Inactivation of retinoblastoma protein does not overcome the requirement for human cytomegalovirus UL97 in lamina disruption and nuclear egress.

Authors: Natalia I Reim; Jeremy P Kamil; Depeng Wang; Alison Lin; Mayuri Sharma; Maria Ericsson; Jean M Pesola; David E Golan; Donald M Coen
Journal: J Virol Date: 2013-02-20 Impact factor: 5.103