Literature DB >> 16801438

A Phe389Leu substitution in ergA confers terbinafine resistance in Aspergillus fumigatus.

E M F Rocha1, R E Gardiner, S Park, N M Martinez-Rossi, D S Perlin.   

Abstract

Replacement of phenylalanine with leucine at position 391 in squalene epoxidase was identified as being responsible for terbinafine resistance in mutants of Aspergillus nidulans. The equivalent mutation was engineered into the ergA gene of Aspergillus fumigatus, resulting in an F389L substitution that also conferred resistance to this pathogenic mold.

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Year:  2006        PMID： 16801438      PMCID： PMC1489775          DOI： 10.1128/AAC.00187-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

Review 1.  Therapeutic potential of terbinafine in subcutaneous and systemic mycoses.

Authors:  R J Hay
Journal:  Br J Dermatol       Date:  1999-11       Impact factor: 9.302

2.  Synergistic interaction of terbinafine with triazoles or amphotericin B against Aspergillus species.

Authors:  N S Ryder; I Leitner
Journal:  Med Mycol       Date:  2001-02       Impact factor: 4.076

3.  Identification of genes involved in terbinafine resistance in Aspergillus nidulans.

Authors:  E M F Rocha; C B Almeida; N M Martinez-Rossi
Journal:  Lett Appl Microbiol       Date:  2002       Impact factor: 2.858

4.  Amino acid substitution in Trichophyton rubrum squalene epoxidase associated with resistance to terbinafine.

Authors:  Colin S Osborne; Ingrid Leitner; Bertrand Favre; Neil S Ryder
Journal:  Antimicrob Agents Chemother       Date:  2005-07       Impact factor: 5.191

5.  A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus.

Authors:  T M Diaz-Guerra; E Mellado; M Cuenca-Estrella; J L Rodriguez-Tudela
Journal:  Antimicrob Agents Chemother       Date:  2003-03       Impact factor: 5.191

6.  Terbinafine resistance mediated by salicylate 1-monooxygenase in Aspergillus nidulans.

Authors:  Marcia A S Graminha; Eleusa M F Rocha; Rolf A Prade; Nilce M Martinez-Rossi
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191

7.  Terbinafine resistance in a pleiotropic yeast mutant is caused by a single point mutation in the ERG1 gene.

Authors:  Vlasta Klobucníková; Peter Kohút; Regina Leber; Sandra Fuchsbichler; Natascha Schweighofer; Friederike Turnowsky; Ivan Hapala
Journal:  Biochem Biophys Res Commun       Date:  2003-09-26       Impact factor: 3.575

8.  Molecular mechanism of terbinafine resistance in Saccharomyces cerevisiae.

Authors:  Regina Leber; Sandra Fuchsbichler; Vlasta Klobucníková; Natascha Schweighofer; Eva Pitters; Kathrin Wohlfarter; Mojca Lederer; Karina Landl; Christoph Ruckenstuhl; Ivan Hapala; Friederike Turnowsky
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191

9.  Extra copies of the Aspergillus fumigatus squalene epoxidase gene confer resistance to terbinafine: genetic approach to studying gene dose-dependent resistance to antifungals in A. fumigatus.

Authors:  Wei Liu; Gregory S May; Michail S Lionakis; Russell E Lewis; Dimitrios P Kontoyiannis
Journal:  Antimicrob Agents Chemother       Date:  2004-07       Impact factor: 5.191

10.  Combination therapy of disseminated Fusarium oxysporum infection with terbinafine and amphotericin B.

Authors:  A Rothe; M Seibold; Th Hoppe; H Seifert; A Engert; C Caspar; M Karthaus; G Fätkenheuer; U Bethe; K Tintelnot; O A Cornely
Journal:  Ann Hematol       Date:  2003-11-27       Impact factor: 3.673
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  8 in total

1.  Mutation in the Squalene Epoxidase Gene of Trichophyton interdigitale and Trichophyton rubrum Associated with Allylamine Resistance.

Authors:  Shivaprakash M Rudramurthy; Shamanth A Shankarnarayan; Sunil Dogra; Dipika Shaw; Khurram Mushtaq; Raees A Paul; Tarun Narang; Arunaloke Chakrabarti
Journal:  Antimicrob Agents Chemother       Date:  2018-04-26       Impact factor: 5.191

2.  Terbinafine Resistance of Trichophyton Clinical Isolates Caused by Specific Point Mutations in the Squalene Epoxidase Gene.

Authors:  Tsuyoshi Yamada; Mari Maeda; Mohamed Mahdi Alshahni; Reiko Tanaka; Takashi Yaguchi; Olympia Bontems; Karine Salamin; Marina Fratti; Michel Monod
Journal:  Antimicrob Agents Chemother       Date:  2017-06-27       Impact factor: 5.191

3.  Characterization of squalene epoxidase of Saccharomyces cerevisiae by applying terbinafine-sensitive variants.

Authors:  Christoph Ruckenstuhl; Silvia Lang; Andrea Poschenel; Armin Eidenberger; Pravas Kumar Baral; Peter Kohút; Ivan Hapala; Karl Gruber; Friederike Turnowsky
Journal:  Antimicrob Agents Chemother       Date:  2006-10-16       Impact factor: 5.191

Review 4.  Anti dermatophytic therapy--prospects for the discovery of new drugs from natural products.

Authors:  Luciana Arantes Soares; Janaína de Cássia Orlandi Sardi; Fernanda Patrícia Gullo; Nayla de Souza Pitangui; Liliana Scorzoni; Fernanda Sangalli Leite; Maria José Soares Mendes Giannini; Ana Marisa Fusco Almeida
Journal:  Braz J Microbiol       Date:  2014-03-10       Impact factor: 2.476

5.  Ergosterol biosynthesis in Aspergillus fumigatus: its relevance as an antifungal target and role in antifungal drug resistance.

Authors:  Laura Alcazar-Fuoli; Emilia Mellado
Journal:  Front Microbiol       Date:  2013-01-10       Impact factor: 5.640

6.  Heat Shock Proteins in Dermatophytes: Current Advances and Perspectives.

Authors:  Nilce M Martinez-Rossi; Tiago R Jacob; Pablo R Sanches; Nalu T A Peres; Elza A S Lang; Maíra P Martins; Antonio Rossi
Journal:  Curr Genomics       Date:  2016-04       Impact factor: 2.236

7.  An Assessment of In Vitro Antifungal Activities of Efinaconazole and Itraconazole against Common Non-Dermatophyte Fungi Causing Onychomycosis.

Authors:  Ananya Tupaki-Sreepurna; Bhavna T Jishnu; Vijayakishore Thanneru; Savitri Sharma; Anjana Gopi; Murugan Sundaram; Anupma Jyoti Kindo
Journal:  J Fungi (Basel)       Date:  2017-05-05

Review 8.  Dermatophyte Resistance to Antifungal Drugs: Mechanisms and Prospectus.

Authors:  Nilce M Martinez-Rossi; Tamires A Bitencourt; Nalu T A Peres; Elza A S Lang; Eriston V Gomes; Natalia R Quaresemin; Maíra P Martins; Lucia Lopes; Antonio Rossi
Journal:  Front Microbiol       Date:  2018-05-29       Impact factor: 5.640
  8 in total

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