Hana Tuby1, Lidya Maltz, Uri Oron. 1. Department of Zoology, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, 69978, Israel.
Abstract
BACKGROUND AND OBJECTIVES: It has been shown previously that low-level laser therapy (LLLT) significantly reduces infarct size following induction of myocardial infarction in rats and dogs. The aim of the present study was to investigate the effect of LLLT on the expression of vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS). STUDY DESIGN AND MATERIAL AND METHODS: Myocardial infarction was induced by occlusion of the left descending artery in 87 rats. LLLT was applied to intact and post-infarction. VEGF, iNOS, and angiogenesis were determined. RESULTS: Both the laser-irradiated rat hearts post-infarction and intact hearts demonstrated a significant increase in VEGF and iNOS expression compared to non-laser-irradiated hearts. LLLT also caused a significant elevation in angiogenesis. CONCLUSIONS: It is concluded that VEGF and iNOS expression in the infarcted rat heart is markedly upregulated by LLLT and is associated with enhanced angiogenesis and cardioprotection. Copyright 2006 Wiley-Liss, Inc.
BACKGROUND AND OBJECTIVES: It has been shown previously that low-level laser therapy (LLLT) significantly reduces infarct size following induction of myocardial infarction in rats and dogs. The aim of the present study was to investigate the effect of LLLT on the expression of vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS). STUDY DESIGN AND MATERIAL AND METHODS:Myocardial infarction was induced by occlusion of the left descending artery in 87 rats. LLLT was applied to intact and post-infarction. VEGF, iNOS, and angiogenesis were determined. RESULTS: Both the laser-irradiated rat hearts post-infarction and intact hearts demonstrated a significant increase in VEGF and iNOS expression compared to non-laser-irradiated hearts. LLLT also caused a significant elevation in angiogenesis. CONCLUSIONS: It is concluded that VEGF and iNOS expression in the infarcted rat heart is markedly upregulated by LLLT and is associated with enhanced angiogenesis and cardioprotection. Copyright 2006 Wiley-Liss, Inc.
Authors: Hoon Chung; Tianhong Dai; Sulbha K Sharma; Ying-Ying Huang; James D Carroll; Michael R Hamblin Journal: Ann Biomed Eng Date: 2011-11-02 Impact factor: 3.934
Authors: Margaret A Naeser; Anita Saltmarche; Maxine H Krengel; Michael R Hamblin; Jeffrey A Knight Journal: Photomed Laser Surg Date: 2010-12-23 Impact factor: 2.796
Authors: Tanupriya Agrawal; Gaurav K Gupta; Vikrant Rai; James D Carroll; Michael R Hamblin Journal: Dose Response Date: 2014-09-22 Impact factor: 2.658
Authors: Ana Paula Cavalcanti de Sousa; Gardênia Matos Paraguassú; Nara Tayene Teixeira Silveira; José de Souza; Maria Cristina Teixeira Cangussú; Jean Nunes dos Santos; Antonio Luiz Barbosa Pinheiro Journal: Lasers Med Sci Date: 2012-08-25 Impact factor: 3.161
Authors: Susana C P Oliveira Sampaio; Juliana S de C Monteiro; Maria Cristina T Cangussú; Gustavo M Pires Santos; Marcos André Vannier dos Santos; Jean Nunes dos Santos; Antonio L B Pinheiro Journal: Lasers Med Sci Date: 2012-07-20 Impact factor: 3.161