BACKGROUND: Poor nutrient intake is conceptualized to be a component of frailty, but this hypothesis has been little investigated. We examined the association between low energy and nutrient intake and frailty. METHODS: We used data from 802 persons aged 65 years or older participating to the InCHIANTI (Invecchiare in Chianti, aging in the Chianti area) study. Frailty was defined by having at least two of the following criteria: low muscle strength, feeling of exhaustion, low walking speed, and reduced physical activity. The European Prospective Investigation into Cancer and nutrition (EPIC) questionnaire was used to estimate the daily intake of energy and nutrients. Low intake was defined using the value corresponding to the lowest sex-specific intake quintile of energy and specific nutrients. Adjusted logistic regression analyses were used to study the association of frailty and frailty criteria with low intakes of energy and nutrients. RESULTS: Daily energy intake < or =21 kcal/kg was significantly associated with frailty (odds ratio [OR]: 1.24; 95% CI: 1.02-1.5). After adjusting for energy intake, a low intake of protein (OR: 1.98; 95% CI: 1.18-3.31); vitamins D (OR: 2.35; 95% CI: 1.48-3.73), E (OR: 2.06; 95% CI: 1.28-3.33), C (OR: 2.15; 95% CI: 1.34-3.45), and folate (OR: 1.84; 95% CI: 1.14-2.98); and having a low intake of more than three nutrients (OR: 2.12; 95% CI: 1.29-3.50) were significantly and independently related to frailty. CONCLUSIONS: This study provides evidence that low intakes of energy and selected nutrients are independently associated with frailty.
BACKGROUND: Poor nutrient intake is conceptualized to be a component of frailty, but this hypothesis has been little investigated. We examined the association between low energy and nutrient intake and frailty. METHODS: We used data from 802 persons aged 65 years or older participating to the InCHIANTI (Invecchiare in Chianti, aging in the Chianti area) study. Frailty was defined by having at least two of the following criteria: low muscle strength, feeling of exhaustion, low walking speed, and reduced physical activity. The European Prospective Investigation into Cancer and nutrition (EPIC) questionnaire was used to estimate the daily intake of energy and nutrients. Low intake was defined using the value corresponding to the lowest sex-specific intake quintile of energy and specific nutrients. Adjusted logistic regression analyses were used to study the association of frailty and frailty criteria with low intakes of energy and nutrients. RESULTS: Daily energy intake < or =21 kcal/kg was significantly associated with frailty (odds ratio [OR]: 1.24; 95% CI: 1.02-1.5). After adjusting for energy intake, a low intake of protein (OR: 1.98; 95% CI: 1.18-3.31); vitamins D (OR: 2.35; 95% CI: 1.48-3.73), E (OR: 2.06; 95% CI: 1.28-3.33), C (OR: 2.15; 95% CI: 1.34-3.45), and folate (OR: 1.84; 95% CI: 1.14-2.98); and having a low intake of more than three nutrients (OR: 2.12; 95% CI: 1.29-3.50) were significantly and independently related to frailty. CONCLUSIONS: This study provides evidence that low intakes of energy and selected nutrients are independently associated with frailty.
Authors: A B Newman; J S Gottdiener; M A Mcburnie; C H Hirsch; W J Kop; R Tracy; J D Walston; L P Fried Journal: J Gerontol A Biol Sci Med Sci Date: 2001-03 Impact factor: 6.053
Authors: L P Fried; C M Tangen; J Walston; A B Newman; C Hirsch; J Gottdiener; T Seeman; R Tracy; W J Kop; G Burke; M A McBurnie Journal: J Gerontol A Biol Sci Med Sci Date: 2001-03 Impact factor: 6.053
Authors: L Ferrucci; S Bandinelli; E Benvenuti; A Di Iorio; C Macchi; T B Harris; J M Guralnik Journal: J Am Geriatr Soc Date: 2000-12 Impact factor: 5.562
Authors: Kate Birnie; Yoav Ben-Shlomo; David Gunnell; Shah Ebrahim; Antony Bayer; John Gallacher; Jeff M P Holly; Richard M Martin Journal: Age Ageing Date: 2012-04-26 Impact factor: 10.668
Authors: M Inzitari; E Doets; B Bartali; V Benetou; M Di Bari; M Visser; S Volpato; G Gambassi; E Topinkova; L De Groot; A Salva Journal: J Nutr Health Aging Date: 2011-08 Impact factor: 4.075
Authors: Benedetta Bartali; Edward A Frongillo; Martha H Stipanuk; Stefania Bandinelli; Simonetta Salvini; Domenico Palli; Jose A Morais; Stefano Volpato; Jack M Guralnik; Luigi Ferrucci Journal: J Am Geriatr Soc Date: 2012-01-27 Impact factor: 5.562
Authors: David R Buys; David L Roth; Christine S Ritchie; Patricia Sawyer; Richard M Allman; Ellen M Funkhouser; Martha Hovater; Julie L Locher Journal: J Gerontol A Biol Sci Med Sci Date: 2014-03-03 Impact factor: 6.053
Authors: L Gregorio; J Brindisi; A Kleppinger; R Sullivan; K M Mangano; J D Bihuniak; A M Kenny; J E Kerstetter; K L Insogna Journal: J Nutr Health Aging Date: 2014 Impact factor: 4.075
Authors: Sameera A Talegawkar; Stefania Bandinelli; Karen Bandeen-Roche; Ping Chen; Yuri Milaneschi; Toshiko Tanaka; Richard D Semba; Jack M Guralnik; Luigi Ferrucci Journal: J Nutr Date: 2012-10-24 Impact factor: 4.798
Authors: J Bollwein; D Volkert; R Diekmann; M J Kaiser; W Uter; K Vidal; C C Sieber; J M Bauer Journal: J Nutr Health Aging Date: 2013-04 Impact factor: 4.075