David H Wyllie1, Derrick W Crook, Tim E A Peto. 1. Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU. david.wyllie@ndcls.ox.ac.uk
Abstract
OBJECTIVE: To determine the incidence of methicillin resistant and methicillin sensitive Staphylococcus aureus (MRSA and MSSA) bacteraemia in inpatients and associated mortality within 30 days after diagnosis. DESIGN: Anonymised record linkage study of data from hospital information systems and microbiology databases. SETTING: Teaching hospital and district general hospital in Oxfordshire. PARTICIPANTS: Inpatients aged 18 or over admitted to a teaching hospital between 1 April 1997 and 31 March 2004 and to a district general hospital between 1 April 1999 and 31 March 2004. The main part of the study comprised 216 644 inpatients; patients admitted to haematology, nephrology, or oncology services were not included because most were managed as outpatients. OUTCOME MEASURES: Nosocomial MSSA and MRSA bacteraemia; death in hospital within 30 days after bacteraemia. RESULTS: Rates of S aureus bacteraemia rose between 1997 and 2003, and MRSA was responsible for this increase. Overall mortality 30 days after bacteraemia was 29%. The crude odds ratio for death after MRSA bacteraemia compared with MSSA bacteraemia was 1.49 (95% confidence interval 0.99 to 2.26). CONCLUSION: The spread of MRSA has greatly increased the overall number of cases of S aureus bacteraemia and has contributed to short term mortality after S aureus bacteraemia.
OBJECTIVE: To determine the incidence of methicillin resistant and methicillin sensitive Staphylococcus aureus (MRSA and MSSA) bacteraemia in inpatients and associated mortality within 30 days after diagnosis. DESIGN: Anonymised record linkage study of data from hospital information systems and microbiology databases. SETTING: Teaching hospital and district general hospital in Oxfordshire. PARTICIPANTS: Inpatients aged 18 or over admitted to a teaching hospital between 1 April 1997 and 31 March 2004 and to a district general hospital between 1 April 1999 and 31 March 2004. The main part of the study comprised 216 644 inpatients; patients admitted to haematology, nephrology, or oncology services were not included because most were managed as outpatients. OUTCOME MEASURES: Nosocomial MSSA and MRSA bacteraemia; death in hospital within 30 days after bacteraemia. RESULTS: Rates of S aureus bacteraemia rose between 1997 and 2003, and MRSA was responsible for this increase. Overall mortality 30 days after bacteraemia was 29%. The crude odds ratio for death after MRSA bacteraemia compared with MSSA bacteraemia was 1.49 (95% confidence interval 0.99 to 2.26). CONCLUSION: The spread of MRSA has greatly increased the overall number of cases of S aureus bacteraemia and has contributed to short term mortality after S aureus bacteraemia.
Authors: G Fätkenheuer; M Preuss; B Salzberger; N Schmeisser; O A Cornely; H Wisplinghoff; H Seifert Journal: Eur J Clin Microbiol Infect Dis Date: 2004-02-25 Impact factor: 3.267
Authors: Allan G Jensen; Carsten H Wachmann; Frank Espersen; Jens Scheibel; Peter Skinhøj; Niels Frimodt-Møller Journal: Arch Intern Med Date: 2002-01-14
Authors: Sara E Cosgrove; George Sakoulas; Eli N Perencevich; Mitchell J Schwaber; Adolf W Karchmer; Yehuda Carmeli Journal: Clin Infect Dis Date: 2002-12-13 Impact factor: 9.079
Authors: R San-Juan; D Pérez-Montarelo; E Viedma; A Lalueza; J Fortún; E Loza; M Pujol; C Ardanuy; I Morales; M de Cueto; E Resino-Foz; M A Morales-Cartagena; M Fernández-Ruiz; A Rico; M P Romero; M Fernández de Mera; F López-Medrano; M Á Orellana; J M Aguado; F Chaves Journal: Eur J Clin Microbiol Infect Dis Date: 2017-05-05 Impact factor: 3.267
Authors: J O Robinson; J C Pearson; K J Christiansen; G W Coombs; R J Murray Journal: Eur J Clin Microbiol Infect Dis Date: 2008-10-11 Impact factor: 3.267