Literature DB >> 16798570

The pharmacologic approach to airway clearance: mucoactive agents.

Bruce K Rubin1.   

Abstract

The term "mucoactive agent" refers to any medication used to improve the clearance of airway secretions. It is not synonymous with the word "mucolytic" as this strictly means a drug that decreases the viscosity of secretions. In many cases, decreased viscosity will adversely affect cough transport. For this reason many of the older mucolytic agents such as acetylcysteine are not effective for the therapy of lung disease and their use is not recommended. I review here the many classes of mucoactive agents and identify a number of medications with great promise for the treatment of chronic airway disease.

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Year:  2006        PMID: 16798570     DOI: 10.1016/j.prrv.2006.04.198

Source DB:  PubMed          Journal:  Paediatr Respir Rev        ISSN: 1526-0542            Impact factor:   2.726


  8 in total

1.  Cylinders vs. spheres: biofluid shear thinning in driven nanoparticle transport.

Authors:  Jeremy A Cribb; Timothy D Meehan; Sheel M Shah; Kwan Skinner; Richard Superfine
Journal:  Ann Biomed Eng       Date:  2010-06-23       Impact factor: 3.934

2.  Nonlinear signatures of entangled polymer solutions in active microbead rheology.

Authors:  J A Cribb; P A Vasquez; P Moore; S Norris; S Shah; M G Forest; R Superfine
Journal:  J Rheol (N Y N Y)       Date:  2013       Impact factor: 4.408

Review 3.  A Primary Care Provider's Guide to Managing Respiratory Health in Subacute and Chronic Spinal Cord Injury.

Authors:  Maria Regina L Reyes; Mary Jo Elmo; Brandon Menachem; Sara Mercedes Granda
Journal:  Top Spinal Cord Inj Rehabil       Date:  2020

Review 4.  Micro- and macrorheology of mucus.

Authors:  Samuel K Lai; Ying-Ying Wang; Denis Wirtz; Justin Hanes
Journal:  Adv Drug Deliv Rev       Date:  2009-01-03       Impact factor: 15.470

5.  Functionalized carboxyl nanoparticles enhance mucus dispersion and hydration.

Authors:  Eric Y Chen; David Daley; Yung-Chen Wang; Maria Garnica; Chi-Shuo Chen; Wei-Chun Chin
Journal:  Sci Rep       Date:  2012-01-05       Impact factor: 4.379

6.  Examination of the Ability of N-acetylcysteine Administration during Anesthesia to Prevent Perioperative Deterioration of Pulmonary Function in Patients Undergoing Nephrectomy.

Authors:  Dea Ja Um; Seok-Joo Hong; Jong Taek Park
Journal:  J Lifestyle Med       Date:  2014-09-30

7.  An optimized protocol for assessment of sputum macrorheology in health and muco-obstructive lung disease.

Authors:  Mirjam Völler; Annalisa Addante; Hanna Rulff; Benjamin von Lospichl; Simon Y Gräber; Julia Duerr; Daniel Lauster; Rainer Haag; Michael Gradzielski; Marcus A Mall
Journal:  Front Physiol       Date:  2022-08-05       Impact factor: 4.755

8.  The Foegen effect: A mechanism by which facemasks contribute to the COVID-19 case fatality rate.

Authors:  Zacharias Fögen
Journal:  Medicine (Baltimore)       Date:  2022-02-18       Impact factor: 1.817

  8 in total

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