Literature DB >> 16798289

Ovarian enzyme activities in women with polycystic ovary syndrome.

Denis A Magoffin1.   

Abstract

Studies using primary ovarian tissue and cultured human theca and granulosa cells have shown that steroidogenic enzyme activities are up-regulated in theca cells in polycystic ovary syndrome (PCOS). Although granulosa cells in arrested follicles in PCOS fail to express significant amounts of aromatase, there is an overexpression of 5alpha-reductase activity and premature expression of cholesterol side-chain cleavage cytochrome P450.

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Year:  2006        PMID： 16798289     DOI： 10.1016/j.fertnstert.2006.03.015

Source DB:  PubMed          Journal:  Fertil Steril        ISSN： 0015-0282            Impact factor:   7.329


  20 in total

1.  Revisiting reproduction: What a difference a gene makes.

Authors:  Bruce D Murphy
Journal:  Nat Med       Date:  2010-05       Impact factor: 53.440

2.  Stimulatory effect of insulin on 5alpha-reductase type 1 (SRD5A1) expression through an Akt-dependent pathway in ovarian granulosa cells.

Authors:  Pradeep P Kayampilly; Brett L Wanamaker; James A Stewart; Carrie L Wagner; K M J Menon
Journal:  Endocrinology       Date:  2010-09-01       Impact factor: 4.736

3.  Luteinizing hormone/human chorionic gonadotropin-mediated activation of mTORC1 signaling is required for androgen synthesis by theca-interstitial cells.

Authors:  Murugesan Palaniappan; K M J Menon
Journal:  Mol Endocrinol       Date:  2012-07-24

4.  AMPK activation by dihydrotestosterone reduces FSH-stimulated cell proliferation in rat granulosa cells by inhibiting ERK signaling pathway.

Authors:  Pradeep P Kayampilly; K M J Menon
Journal:  Endocrinology       Date:  2012-03-27       Impact factor: 4.736

5.  Genetic association study from North India to analyze association of CYP19A1 and CYP17A1 with polycystic ovary syndrome.

Authors:  Ratneev Kaur; Tajinder Kaur; Anupam Kaur
Journal:  J Assist Reprod Genet       Date:  2018-03-22       Impact factor: 3.412

Review 6.  Functional genomics of PCOS: from GWAS to molecular mechanisms.

Authors:  Jan M McAllister; Richard S Legro; Bhavi P Modi; Jerome F Strauss
Journal:  Trends Endocrinol Metab       Date:  2015-01-15       Impact factor: 12.015

7.  Human chorionic gonadotropin stimulates theca-interstitial cell proliferation and cell cycle regulatory proteins by a cAMP-dependent activation of AKT/mTORC1 signaling pathway.

Authors:  Murugesan Palaniappan; K M J Menon
Journal:  Mol Endocrinol       Date:  2010-07-21

8.  Establishment and characterization of a PCOS and a normal human granulosa cell line.

Authors:  Zohreh Hashemian; Parvaneh Afsharian; Parvaneh Farzaneh; Poopak Eftekhari-Yazdi; Faezeh Vakhshiteh; Abdolreza Daneshvar Amoli; Ahmad Nasimian
Journal:  Cytotechnology       Date:  2020-09-28       Impact factor: 2.058

Review 9.  Ovarian and adipose tissue dysfunction in polycystic ovary syndrome: report of the 4th special scientific meeting of the Androgen Excess and PCOS Society.

Authors:  Bulent O Yildiz; Ricardo Azziz
Journal:  Fertil Steril       Date:  2009-04-25       Impact factor: 7.329

10.  Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype.

Authors:  Jan M McAllister; Bhavi Modi; Bruce A Miller; Jessica Biegler; Richard Bruggeman; Richard S Legro; Jerome F Strauss
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-31       Impact factor: 11.205
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