| Literature DB >> 16798286 |
Francis de Zegher1, Lourdes Ibáñez.
Abstract
One of the pathways to polycystic ovary syndrome (PCOS) starts with an early-life sequence of prenatal growth restraint followed by catch-up of weight during infancy. This sequence results by mid-childhood in a pre-PCOS state including hyperinsulinemia, a low-grade proinflammatory state, an amplified adrenarche (with or without precocious pubarche), and an adipose body composition even in the absence of obesity. This variant of pre-PCOS and PCOS responds well to intervention with metformin.Entities:
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Year: 2006 PMID： 16798286 DOI： 10.1016/j.fertnstert.2006.03.013
Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329