Literature DB >> 16797735

L-nucleoside enantiomers as antivirals drugs: a mini-review.

Christophe Mathé1, Gilles Gosselin.   

Abstract

The discovery that some nucleoside analogues endowed with the unnatural L-configuration can possess biological activities has been a significant breakthrough in antiviral chemotherapy. In this regard, lamivudine (3TC) was the first L-nucleoside enantiomer approved against HIV and HBV, and several other L-nucleosides are currently under clinical development as antiviral agents.

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Year:  2006        PMID： 16797735     DOI： 10.1016/j.antiviral.2006.04.017

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  33 in total

1.  Palladium-catalyzed asymmetric allylic alkylation of electron-deficient pyrroles with meso electrophiles.

Authors:  Barry M Trost; Maksim Osipov; Guangbin Dong
Journal:  Org Lett       Date:  2012-04-16       Impact factor: 6.005

Review 2.  Structural modifications of nucleosides in ionic liquids.

Authors:  Vineet Kumar; Virinder S Parmar; Sanjay V Malhotra
Journal:  Biochimie       Date:  2010-02-21       Impact factor: 4.079

3.  Treatment of Venezuelan equine encephalitis virus infection with (-)-carbodine.

Authors:  Justin G Julander; Richard A Bowen; Jagadeeshwar R Rao; Craig Day; Kristiina Shafer; Donald F Smee; John D Morrey; Chung K Chu
Journal:  Antiviral Res       Date:  2008-08-15       Impact factor: 5.970

4.  A spring-loaded release mechanism regulates domain movement and catalysis in phosphoglycerate kinase.

Authors:  Louiza Zerrad; Angelo Merli; Gunnar F Schröder; Andrea Varga; Éva Gráczer; Petra Pernot; Adam Round; Mária Vas; Matthew W Bowler
Journal:  J Biol Chem       Date:  2011-02-24       Impact factor: 5.157

5.  Heterologous expression and characterization of Bacillus coagulans L-arabinose isomerase.

Authors:  Xingding Zhou; Jin Chuan Wu
Journal:  World J Microbiol Biotechnol       Date:  2012-02-19       Impact factor: 3.312

6.  Acetoxy Meldrum's acid: a versatile acyl anion equivalent in the Pd-catalyzed asymmetric allylic alkylation.

Authors:  Barry M Trost; Maksim Osipov; Philip S J Kaib; Mark T Sorum
Journal:  Org Lett       Date:  2011-05-26       Impact factor: 6.005

7.  The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analogues.

Authors:  Saugata Hazra; Manfred Konrad; Arnon Lavie
Journal:  J Med Chem       Date:  2010-08-12       Impact factor: 7.446

8.  Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides.

Authors:  Hong-Wang Zhang; Mervi Detorio; Brian D Herman; Sarah Solomon; Leda Bassit; James H Nettles; Aleksandr Obikhod; Si-Jia Tao; John W Mellors; Nicolas Sluis-Cremer; Steven J Coats; Raymond F Schinazi
Journal:  Eur J Med Chem       Date:  2011-05-30       Impact factor: 6.514

9.  Inhibition of guanosine monophosphate synthetase by the substrate enantiomer L-XMP.

Authors:  Nicholas B Struntz; Tianshun Hu; Brian R White; Margaret E Olson; Daniel A Harki
Journal:  Chembiochem       Date:  2012-10-23       Impact factor: 3.164

10.  Factors affecting the production of L-xylulose by resting cells of recombinant Escherichia coli.

Authors:  Anne Usvalampi; Kristiina Kiviharju; Matti Leisola; Antti Nyyssölä
Journal:  J Ind Microbiol Biotechnol       Date:  2009-07-15       Impact factor: 3.346
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