BACKGROUND: South Asians, especially Indians show increased risk for atherosclerosis and have the higher mortality rates due to coronary artery disease. The increasing incidence of coronary artery disease in young patients is possibly due to industrialization, stress of life, less exercise and increasing incidence of smoking and other factors. We attempted to determine an independent association of paraoxonase with coronary artery disease in young patients. METHOD: The lipid profile and serum paraoxonase were investigated in 120 angiographically-proven premature coronary artery disease patients (99 males and 21 females, all <45 years) with diabetes mellitus, smoking, hyperlipidemia, obesity, hypertension along with 50 (41 male and 9 female) normal subjects and compared. RESULTS: A significant increase was observed in the concentrations of total cholesterol, triglycerides and LDL cholesterol in premature coronary artery disease patients. The activities of paraoxonase and HDL cholesterol concentrations decreased in coronary artery disease patients compared to control subjects. CONCLUSION: A paraoxonase was an independent (p<0.001, OR 14.9 and 95% CI 5.6-35.9) risk factor for premature coronary artery disease patients along with lipid profiles. Paraoxonase activity should be evaluated in all coronary artery disease patients in the absence of traditional risk factors.
BACKGROUND: South Asians, especially Indians show increased risk for atherosclerosis and have the higher mortality rates due to coronary artery disease. The increasing incidence of coronary artery disease in young patients is possibly due to industrialization, stress of life, less exercise and increasing incidence of smoking and other factors. We attempted to determine an independent association of paraoxonase with coronary artery disease in young patients. METHOD: The lipid profile and serum paraoxonase were investigated in 120 angiographically-proven premature coronary artery diseasepatients (99 males and 21 females, all <45 years) with diabetes mellitus, smoking, hyperlipidemia, obesity, hypertension along with 50 (41 male and 9 female) normal subjects and compared. RESULTS: A significant increase was observed in the concentrations of total cholesterol, triglycerides and LDL cholesterol in premature coronary artery diseasepatients. The activities of paraoxonase and HDL cholesterol concentrations decreased in coronary artery diseasepatients compared to control subjects. CONCLUSION: A paraoxonase was an independent (p<0.001, OR 14.9 and 95% CI 5.6-35.9) risk factor for premature coronary artery diseasepatients along with lipid profiles. Paraoxonase activity should be evaluated in all coronary artery diseasepatients in the absence of traditional risk factors.
Authors: Maharudra Shekhanawar; Sarala M Shekhanawar; D Krisnaswamy; V Indumati; D Satishkumar; V Vijay; T Rajeshwari; M Amareshwar Journal: J Clin Diagn Res Date: 2013-07-01
Authors: Roya S Moheimani; May Bhetraratana; Kacey M Peters; Benjamin K Yang; Fen Yin; Jeffrey Gornbein; Jesus A Araujo; Holly R Middlekauff Journal: J Am Heart Assoc Date: 2017-09-20 Impact factor: 5.501
Authors: Zachary Boas; Pawan Gupta; Roya S Moheimani; May Bhetraratana; Fen Yin; Kacey M Peters; Jeffrey Gornbein; Jesus A Araujo; Johannes Czernin; Holly R Middlekauff Journal: Physiol Rep Date: 2017-09