Y Inoue1, K Yamada, S Kanba. 1. Department of Neuropsychiatry, Inogashira Hospital, Tokyo, Japan.
Abstract
BACKGROUND: Recently, we reported that patients with depression have theory of mind (ToM) deficit during remission from acute episodes. ToM deficit means difficulty in social adjustment and thus may indicate a poorer prognosis. METHODS: We evaluated ToM ability of 50 patients during remission from major depressive episodes. The patients were followed for 1 year and their outcome observed. RESULTS: After 1 year, patients who had ToM deficit in a second order false question relapsed significantly more frequently as compared with patients who did not have a deficit (Fisher's exact test p < 0.0001; relative risk (RR) = 8.105; CI 2.020, 32.524). Significant differences were shown in scores of the Global Assessment of Functioning Scale (p < 0.0001) between the two groups. CONCLUSIONS: Patients with ToM deficit in second order false belief during remission may be a high risk group for recurrence and lower social function 1 year after recovering from a major depressive episode.
BACKGROUND: Recently, we reported that patients with depression have theory of mind (ToM) deficit during remission from acute episodes. ToM deficit means difficulty in social adjustment and thus may indicate a poorer prognosis. METHODS: We evaluated ToM ability of 50 patients during remission from major depressive episodes. The patients were followed for 1 year and their outcome observed. RESULTS: After 1 year, patients who had ToM deficit in a second order false question relapsed significantly more frequently as compared with patients who did not have a deficit (Fisher's exact test p < 0.0001; relative risk (RR) = 8.105; CI 2.020, 32.524). Significant differences were shown in scores of the Global Assessment of Functioning Scale (p < 0.0001) between the two groups. CONCLUSIONS:Patients with ToM deficit in second order false belief during remission may be a high risk group for recurrence and lower social function 1 year after recovering from a major depressive episode.
Authors: Andrée M Cusi; Anthony Nazarov; Katherine Holshausen; Glenda M Macqueen; Margaret C McKinnon Journal: J Psychiatry Neurosci Date: 2012-05 Impact factor: 6.186
Authors: Michael J Gawrysiak; John P Carvalho; Baxter P Rogers; Christopher R N Nicholas; John H Dougherty; Derek R Hopko Journal: Case Rep Psychiatry Date: 2012-05-09