Literature DB >> 16796355

Comparative study of the fluid dynamics of bottom spray fluid bed coaters.

L W Chan1, Elaine S K Tang, Paul W S Heng.   

Abstract

Fluid dynamics of pellets processed in bottom spray traditional Wurster coating and swirl accelerated air (precision) coating were compared with the intent to understand and facilitate improvements in the coating processes. Fluid dynamics was described by pellet mass flow rate (MFR) obtained using a pellet collection system and images captured using high speed photography. Pellet flow within the partition column was found to be denser and slower in Wurster coating than in precision coating, suggesting a higher tendency of agglomeration during the coating process. The influence of partition gap and load on the MFR indicated that the mechanism of transport of pellets into the coating zone in precision coating depended on a strong suction, whereas in Wurster coating, pellets were transported by a combination of peripheral fluidization, gravity, and weak suction pressure. In precision coating, MFR was found to increase uniformly with air flow rate and atomizing pressure, whereas MFR in Wurster coating did not correlate as well with air flow rate and atomizing pressure. This demonstration showed that transport in precision coating was air dominated. In conclusion, fluid dynamics in precision coating was found to be air dominated and dependent on pressure differential, thus it is more responsive to changes in operational variables than Wurster coating.

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Year:  2006        PMID: 16796355     DOI: 10.1208/pt070237

Source DB:  PubMed          Journal:  AAPS PharmSciTech        ISSN: 1530-9932            Impact factor:   3.246


  3 in total

1.  Classification of annular bed flow patterns and investigation on their influence on the bottom spray fluid bed coating process.

Authors:  Li Kun Wang; Paul Wan Sia Heng; Celine Valeria Liew
Journal:  Pharm Res       Date:  2010-03-05       Impact factor: 4.200

2.  A feasibility study on pellet coating using a high-speed quasi-continuous coater.

Authors:  Christine Cahyadi; Jackson Jie Sheng Koh; Zhi Hui Loh; Lai Wah Chan; Paul Wan Sia Heng
Journal:  AAPS PharmSciTech       Date:  2012-09-21       Impact factor: 3.246

3.  Investigation of Hydrodynamic Behavior of Alginate Aerogel Particles in a Laboratory Scale Wurster Fluidized Bed.

Authors:  Işık Sena Akgün; Can Erkey
Journal:  Molecules       Date:  2019-08-11       Impact factor: 4.411

  3 in total

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