BACKGROUND/AIM: We have recently reported the development of oxidative cell damages in bombing casualties within a very early period after the initial injury. The aim of this study, was to investigate malondialdehyde (MDA), as an indicator of lipid peroxidation, and osmolal gap (OG), as a good indicator of metabolic cell damages and to assess their relationship with the initial severity of the injury in bombing casualties. METHODS: The study included the males (n = 52), injured during the bombing with the Injury Severity Score (ISS) ranging from 3 to 66. The whole group of casualties was devided into a group of less severely (ISS < 25, n = 24) and a group of severely (ISS > or = 26, n = 28) injured males. The uninjured volunteers (n = 10) were the controls. Osmolality, MDA, sodium, glucose, urea, creatinine, total bilirubin and total protein levels were measured in the venous blood, sampled daily, within a ten-day period. RESULTS: In both groups of casualties, MDA and OG levels increased, total protein levels decreased, while other parameters were within the control limits. MDA alterations correlated with ISS (r = 0.414, p < 0.01), while a statistically significant correlation between OG and ISS was not obtained. Interestingly, in spite of some differences in MDA and OG trends, at the end of the examined period they were at the similar level in both groups. CONCLUSION: The initial oxidative damages of the cellular membrane with intracellular metabolic disorders contributed to the gradual development of metabolic-osmotic damages of cells, which, consequently caused the OG increase. In the bombing casualties, oxidative cell damages were dependent on the initial injury severity, while metabolic-osmotic cell damages were not.
BACKGROUND/AIM: We have recently reported the development of oxidative cell damages in bombing casualties within a very early period after the initial injury. The aim of this study, was to investigate malondialdehyde (MDA), as an indicator of lipid peroxidation, and osmolal gap (OG), as a good indicator of metabolic cell damages and to assess their relationship with the initial severity of the injury in bombing casualties. METHODS: The study included the males (n = 52), injured during the bombing with the Injury Severity Score (ISS) ranging from 3 to 66. The whole group of casualties was devided into a group of less severely (ISS < 25, n = 24) and a group of severely (ISS > or = 26, n = 28) injured males. The uninjured volunteers (n = 10) were the controls. Osmolality, MDA, sodium, glucose, urea, creatinine, total bilirubin and total protein levels were measured in the venous blood, sampled daily, within a ten-day period. RESULTS: In both groups of casualties, MDA and OG levels increased, total protein levels decreased, while other parameters were within the control limits. MDA alterations correlated with ISS (r = 0.414, p < 0.01), while a statistically significant correlation between OG and ISS was not obtained. Interestingly, in spite of some differences in MDA and OG trends, at the end of the examined period they were at the similar level in both groups. CONCLUSION: The initial oxidative damages of the cellular membrane with intracellular metabolic disorders contributed to the gradual development of metabolic-osmotic damages of cells, which, consequently caused the OG increase. In the bombing casualties, oxidative cell damages were dependent on the initial injury severity, while metabolic-osmotic cell damages were not.
Authors: Hale Z Toklu; Judy Muller-Delp; Zhihui Yang; Şehkar Oktay; Yasemin Sakarya; Kevin Strang; Payal Ghosh; Michael D Delp; Philip J Scarpace; Kevin K W Wang; Nihal Tümer Journal: J Cereb Blood Flow Metab Date: 2015-06-24 Impact factor: 6.200
Authors: Firas Kobeissy; Stefania Mondello; Nihal Tümer; Hale Z Toklu; Melissa A Whidden; Nataliya Kirichenko; Zhiqun Zhang; Victor Prima; Walid Yassin; John Anagli; Namas Chandra; Stan Svetlov; Kevin K W Wang Journal: Front Neurol Date: 2013-11-21 Impact factor: 4.003
Authors: Abbas Jarrahi; Molly Braun; Meenakshi Ahluwalia; Rohan V Gupta; Michael Wilson; Stephanie Munie; Pankaj Ahluwalia; John R Vender; Fernando L Vale; Krishnan M Dhandapani; Kumar Vaibhav Journal: Biomedicines Date: 2020-09-29