OBJECTIVE: The purpose of the study was to quantify the fat fraction in nine fat-water phantoms containing 0-80% fat using opposed-phase imaging with the qualitative guidance of 1H MR spectroscopy (MRS), which was used by observer 1 to visually assess the sizes of the water and fat peaks to apply two alternative mathematic formulas for the calculation of the fat fraction. In addition, the fat fraction was also quantified directly with 1H MRS as an independent method by two observers (observers 2 and 3). CONCLUSION: The fat fraction calculated with opposed-phase imaging (FF(OPI)) and that calculated with 1H MRS (FF(MRS)) correlated well with the known fat fractions of the phantoms (FF(P)): r = 0.99 for FF(OPI); p < 0.0001 and r = 0.96-0.98 for FF(MRS); p < 0.001, for observers 2 and 3, respectively. Opposed-phase imaging should be combined with 1H MRS to ensure accurate quantification of the fat fraction.
OBJECTIVE: The purpose of the study was to quantify the fat fraction in nine fat-water phantoms containing 0-80% fat using opposed-phase imaging with the qualitative guidance of 1H MR spectroscopy (MRS), which was used by observer 1 to visually assess the sizes of the water and fat peaks to apply two alternative mathematic formulas for the calculation of the fat fraction. In addition, the fat fraction was also quantified directly with 1H MRS as an independent method by two observers (observers 2 and 3). CONCLUSION: The fat fraction calculated with opposed-phase imaging (FF(OPI)) and that calculated with 1H MRS (FF(MRS)) correlated well with the known fat fractions of the phantoms (FF(P)): r = 0.99 for FF(OPI); p < 0.0001 and r = 0.96-0.98 for FF(MRS); p < 0.001, for observers 2 and 3, respectively. Opposed-phase imaging should be combined with 1H MRS to ensure accurate quantification of the fat fraction.
Authors: Jens-Peter Kühn; Diego Hernando; Birger Mensel; Paul C Krüger; Till Ittermann; Julia Mayerle; Norbert Hosten; Scott B Reeder Journal: J Magn Reson Imaging Date: 2013-10-10 Impact factor: 4.813
Authors: Huanzhou Yu; Ann Shimakawa; Catherine D G Hines; Charles A McKenzie; Gavin Hamilton; Claude B Sirlin; Jean H Brittain; Scott B Reeder Journal: Magn Reson Med Date: 2011-02-24 Impact factor: 4.668
Authors: Jens-Peter Kühn; Friederike Berthold; Julia Mayerle; Henry Völzke; Scott B Reeder; Wolfgang Rathmann; Markus M Lerch; Norbert Hosten; Katrin Hegenscheid; Peter J Meffert Journal: Radiology Date: 2015-02-05 Impact factor: 11.105
Authors: Jens-Peter Kühn; Christina Jahn; Diego Hernando; Werner Siegmund; Stefan Hadlich; Julia Mayerle; Jörg Pfannmöller; Sonke Langner; Scott Reeder Journal: J Magn Reson Imaging Date: 2013-11-15 Impact factor: 4.813
Authors: Lena J Vogt; Antje Steveling; Peter J Meffert; Marie-Luise Kromrey; Rebecca Kessler; Norbert Hosten; Janine Krüger; Simone Gärtner; Ali A Aghdassi; Julia Mayerle; Markus M Lerch; Jens-Peter Kühn Journal: PLoS One Date: 2016-04-25 Impact factor: 3.240