Literature DB >> 1679337

Dopamine agonists potentiate antiakinetic effects of competitive NMDA-antagonists in monoamine-depleted mice.

K Kannari1, R Markstein.   

Abstract

The competitive NMDA-antagonists SDZ EAA-494 and CGP 37849 and the mixed D-1/D-2 dopamine agonists CI 201-678 and SDZ 205-152 reverse akinesia in monoamine-depleted mice in a dose dependent manner. Combination of threshold doses of NMDA-antagonists with dopamine agonists markedly enhances anti-akinetic effects. CI 201-678 which in addition to D-1 and D-2 receptors stimulates alpha-2 receptors produces a stronger effect than SDZ 205-152 which is devoid of alpha-2 agonist activity. The results indicate that concomitant blockade of NMDA-receptors and activation of dopamine receptors results in synergistic or at least additive motor stimulatory effects.

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Year:  1991        PMID： 1679337     DOI： 10.1007/bf01244971

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  13 in total

Review 1.  The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system.

Authors:  D T Monaghan; R J Bridges; C W Cotman
Journal:  Annu Rev Pharmacol Toxicol       Date:  1989       Impact factor: 13.820

2.  Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines.

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Journal:  Neuroscience       Date:  1984-12       Impact factor: 3.590

Review 3.  Glutamate: a neurotransmitter in mammalian brain.

Authors:  F Fonnum
Journal:  J Neurochem       Date:  1984-01       Impact factor: 5.372

4.  Mechanism of kainate toxicity to cerebellar neurons in vitro is analogous to reperfusion tissue injury.

Authors:  J A Dykens; A Stern; E Trenkner
Journal:  J Neurochem       Date:  1987-10       Impact factor: 5.372

5.  The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice.

Authors:  M Carlsson; A Carlsson
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575

6.  Dramatic synergism between MK-801 and clonidine with respect to locomotor stimulatory effect in monoamine-depleted mice.

Authors:  M Carlsson; A Carlsson
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575

7.  Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain.

Authors:  D T Monaghan; C W Cotman
Journal:  J Neurosci       Date:  1985-11       Impact factor: 6.167

8.  CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-aspartate receptor antagonists with oral activity.

Authors:  G E Fagg; H R Olpe; M F Pozza; J Baud; M Steinmann; M Schmutz; C Portet; P Baumann; K Thedinga; H Bittiger
Journal:  Br J Pharmacol       Date:  1990-04       Impact factor: 8.739

9.  Intrastriatal injection of DL-2-amino-5-phosphonovaleric acid (AP-5) induces sniffing stereotypy that is antagonized by haloperidol and clozapine.

Authors:  W J Schmidt
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

10.  Interactions between dopamine and amino acid-induced excitation and inhibition in the striatum.

Authors:  L A Chiodo; T W Berger
Journal:  Brain Res       Date:  1986-06-04       Impact factor: 3.252
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  6 in total

1.  Restoration and putative protection in Parkinsonism.

Authors:  T Archer; A Fredriksson
Journal:  Neurotox Res       Date:  2000       Impact factor: 3.911

2.  Co-administration of memantine and amantadine with sub/suprathreshold doses of L-Dopa restores motor behaviour of MPTP-treated mice.

Authors:  A Fredriksson; W Danysz; G Quack; T Archer
Journal:  J Neural Transm (Vienna)       Date:  2001       Impact factor: 3.575

3.  Synergistic interactions between NMDA-antagonists and L-dopa on activity in MPTP-treated mice.

Authors:  A Fredriksson; C Gentsch; T Archer
Journal:  J Neural Transm Gen Sect       Date:  1994

4.  Effects of dopamine D1 and D2 receptor blockade on MK-801-induced hyperlocomotion in rats.

Authors:  A Ouagazzal; A Nieoullon; M Amalric
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

5.  Centrally-administered glycine antagonists increase locomotion in monoamine-depleted mice.

Authors:  B Stauch Slusher; K C Rissolo; P F Jackson; L M Pullan
Journal:  J Neural Transm Gen Sect       Date:  1994

6.  Differential locomotor interactions between dopamine D1/D2 receptor agonists and the NMDA antagonist dizocilpine in monoamine-depleted mice.

Authors:  A Svensson; A Carlsson; M L Carlsson
Journal:  J Neural Transm Gen Sect       Date:  1992
  6 in total

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