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Literature DB >> 16793267

Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation.

Benjamin E Blass¹, Keith Coburn, Wenlin Lee, Neil Fairweather, Andrew Fluxe, Shengde Wu, John M Janusz, Michael Murawsky, Gina M Fadayel, Bin Fang, Michelle Hare, Jim Ridgeway, Ron White, Chris Jackson, Laurent Djandjighian, Richard Hedges, Fred C Wireko, Amanda L Ritter.

Abstract

A series of novel (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones were prepared and examined for utility as Kv1.5 channel blockers for the treatment of atrial fibrillation.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2006 PMID： 16793267 DOI： 10.1016/j.bmcl.2006.06.001

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

6 in total

1. Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

Authors: Ute F Röhrig; Somi Reddy Majjigapu; Pierre Vogel; Aline Reynaud; Florence Pojer; Nahzli Dilek; Patrick Reichenbach; Kelly Ascenção; Melita Irving; George Coukos; Olivier Michielin; Vincent Zoete
Journal: J Enzyme Inhib Med Chem Date: 2022-12 Impact factor: 5.756

2. N²-selective alkylation of NH-1,2,3-triazoles with vinyl ethers via gold catalysis.

Authors: Guoli Luo; Chenyang Sun; Yan Li; Xiaoxiao Li; Zhigang Zhao
Journal: RSC Adv Date: 2018-08-02 Impact factor: 4.036

3. In situ generation of N-unsubstituted imines from alkyl azides and their applications for imine transfer via copper catalysis.

Authors: Lu Hu; Yahu A Liu; Xuebin Liao
Journal: Sci Adv Date: 2017-08-09 Impact factor: 14.136

Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation.

1. Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

2. N²-selective alkylation of NH-1,2,3-triazoles with vinyl ethers via gold catalysis.

3. In situ generation of N-unsubstituted imines from alkyl azides and their applications for imine transfer via copper catalysis.

4. Synthesis of Tris-Heterocycles via a Cascade IMCR/Aza Diels-Alder + CuAAC Strategy.

5. Selective Synthesis of Azoloyl NH-1,2,3-Triazoles and Azolyl Diazoketones: Experimental and Computational Insights.

Review 6. Challenges Faced with Small Molecular Modulators of Potassium Current Channel Isoform Kv1.5.

Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation.

1. Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

2. N2-selective alkylation of NH-1,2,3-triazoles with vinyl ethers via gold catalysis.

3. In situ generation of N-unsubstituted imines from alkyl azides and their applications for imine transfer via copper catalysis.

4. Synthesis of Tris-Heterocycles via a Cascade IMCR/Aza Diels-Alder + CuAAC Strategy.

5. Selective Synthesis of Azoloyl NH-1,2,3-Triazoles and Azolyl Diazoketones: Experimental and Computational Insights.

Review 6. Challenges Faced with Small Molecular Modulators of Potassium Current Channel Isoform Kv1.5.

2. N²-selective alkylation of NH-1,2,3-triazoles with vinyl ethers via gold catalysis.