Literature DB >> 16793264

Potent 4-amino-5-azaindole factor VIIa inhibitors.

Huiyong Hu1, Aleksandr Kolesnikov, Jennifer R Riggs, Kieron E Wesson, Robin Stephens, Ellen M Leahy, William D Shrader, Paul A Sprengeler, Michael J Green, Ellen Sanford, Margaret Nguyen, Erik Gjerstad, Ronnel Cabuslay, Wendy B Young.   

Abstract

The 4-amino-5-azaindole as an amidino-benzimidazole replacement is described. A series of potent and selective analogs were discovered and showed desirable ex vivo efficacy as measured by PT.

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Year:  2006        PMID: 16793264     DOI: 10.1016/j.bmcl.2006.06.016

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors.

Authors:  Xiaojun Zhang; Wen Jiang; Swanee Jacutin-Porte; Peter W Glunz; Yan Zou; Xuhong Cheng; Alexandra H Nirschl; Nicholas R Wurtz; Joseph M Luettgen; Alan R Rendina; Gang Luo; Timothy M Harper; Anzhi Wei; Rushith Anumula; Daniel L Cheney; Robert M Knabb; Pancras C Wong; Ruth R Wexler; E Scott Priestley
Journal:  ACS Med Chem Lett       Date:  2013-12-26       Impact factor: 4.345

2.  Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors.

Authors:  Michael Lainchbury; Thomas P Matthews; Tatiana McHardy; Kathy J Boxall; Michael I Walton; Paul D Eve; Angela Hayes; Melanie R Valenti; Alexis K de Haven Brandon; Gary Box; G Wynne Aherne; John C Reader; Florence I Raynaud; Suzanne A Eccles; Michelle D Garrett; Ian Collins
Journal:  J Med Chem       Date:  2012-10-19       Impact factor: 7.446

  2 in total

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