Literature DB >> 16792847

Sperm nuclear DNA damage: update on the mechanism, diagnosis and treatment.

Jan Tesarik1, Raquel Mendoza-Tesarik, Carmen Mendoza.   

Abstract

Previous studies have shown that repeated intracytoplasmic sperm injection failures can be associated with sperm DNA damage. This paper reviews the current understanding of the mechanism of sperm DNA damage, discusses different diagnostic methods and their threshold values to discriminate between good- and poor-prognosis patients, and outlines the currently available treatment options. A rational approach to the interpretation of sperm DNA fragmentation data and to the choice of the optimal treatment method is suggested.

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Year:  2006        PMID： 16792847     DOI： 10.1016/s1472-6483(10)61083-8

Source DB:  PubMed          Journal:  Reprod Biomed Online        ISSN： 1472-6483            Impact factor:   3.828


  12 in total

1.  Aging in male primates: reproductive decline, effects of calorie restriction and future research potential.

Authors:  Brandon D Sitzmann; Henryk F Urbanski; Mary Ann Ottinger
Journal:  Age (Dordr)       Date:  2008-07-09

Review 2.  Sperm DNA integrity assays: diagnostic and prognostic challenges and implications in management of infertility.

Authors:  Monis Bilal Shamsi; Syed Nazar Imam; Rima Dada
Journal:  J Assist Reprod Genet       Date:  2011-09-09       Impact factor: 3.412

3.  Effects of highly purified follicle-stimulating hormone on sperm DNA damage in men with male idiopathic subfertility: a pilot study.

Authors:  S Palomba; A Falbo; S Espinola; M Rocca; S Capasso; F Cappiello; F Zullo
Journal:  J Endocrinol Invest       Date:  2011-05-23       Impact factor: 4.256

4.  Serum Levels of Melatonin and Oxidative Stress Markers and Correlation between Them in Infertile Men.

Authors:  Sara Soleimani Rad; Shamsi Abbasalizadeh; Amir Ghorbani Haghjo; Mehzad Sadagheyani; Azadeh Montaseri; Jafar Soleimani Rad
Journal:  J Caring Sci       Date:  2013-11-30

5.  Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice.

Authors:  Eléonore Chabory; Christelle Damon; Alain Lenoir; Gary Kauselmann; Hedrun Kern; Branko Zevnik; Catherine Garrel; Fabrice Saez; Rémi Cadet; Joelle Henry-Berger; Michael Schoor; Ulrich Gottwald; Ursula Habenicht; Joël R Drevet; Patrick Vernet
Journal:  J Clin Invest       Date:  2009-06-22       Impact factor: 14.808

6.  Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice.

Authors:  Anaïs Noblanc; Manon Peltier; Christelle Damon-Soubeyrand; Nicolas Kerchkove; Eléonore Chabory; Patrick Vernet; Fabrice Saez; Rémi Cadet; Laurent Janny; Hanae Pons-Rejraji; Marcus Conrad; Joël R Drevet; Ayhan Kocer
Journal:  PLoS One       Date:  2012-06-14       Impact factor: 3.240

7.  Clinical scenarios of unexplained sperm DNA fragmentation and their management.

Authors:  Jan Tesarik; Maribel Galán-Lázaro
Journal:  Transl Androl Urol       Date:  2017-09

Review 8.  Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes.

Authors:  Ashok Agarwal; Reda Z Mahfouz; Rakesh K Sharma; Oli Sarkar; Devna Mangrola; Premendu P Mathur
Journal:  Reprod Biol Endocrinol       Date:  2009-12-05       Impact factor: 5.211

9.  Sperm chromatin integrity: etiologies and mechanisms of abnormality, assays, clinical importance, preventing and repairing damage.

Authors:  Azita Hekmatdoost; Niknam Lakpour; Mohammad Reza Sadeghi
Journal:  Avicenna J Med Biotechnol       Date:  2009-10

10.  Relationship between sperm protamine deficiency and apoptosis in couples with unexplained repeated spontaneous abortions.

Authors:  Ali Reza Talebi; Farzaneh Fesahat; Esmat Mangoli; Jalal Ghasemzadeh; Maryam Nayeri; Fatemeh Sadeghian-Nodoshan
Journal:  Int J Reprod Biomed       Date:  2016-03
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