P Merkus1, F A Ebbens, B Muller, W J Fokkens. 1. Department of Otorhinolaryngology & Head and Neck Surgery, VU Medical Center, Amsterdam, Netherlands. P.Merkus@VUmc.nl
Abstract
OBJECTIVE: To determine whether there is a 'best' technique for delivering drugs to the middle meatus. DESIGN: Single-blind cross-over study in healthy individuals using endoscopic video-imaging. PARTICIPANTS: A dyed test formulation was administered intranasally on seven non-sequential days to ten healthy individuals with no 'nasal' history. The participants were recruited through advertisement. MAIN OUTCOME MEASURES: Comparison of seven different techniques, 20 nostrils and 140 endoscopic videos for the deposition patterns of dyed test formulation. Analysis was possible in 90% of all endoscopic videos. Three head positions were tested for both nasal drops and nasal sprays. RESULTS: Deposition of dyed test formulation near the middle meatus was observed in 43% of all observations. No significant differences were observed in terms of delivery between any of the seven techniques. CONCLUSIONS: Our study suggests there may not be a single 'best' technique for topical nasal drug delivery. A more individual approach to topical nasal drug treatment, taking anatomy and head position into account would seem to be more appropriate.
RCT Entities:
OBJECTIVE: To determine whether there is a 'best' technique for delivering drugs to the middle meatus. DESIGN: Single-blind cross-over study in healthy individuals using endoscopic video-imaging. PARTICIPANTS: A dyed test formulation was administered intranasally on seven non-sequential days to ten healthy individuals with no 'nasal' history. The participants were recruited through advertisement. MAIN OUTCOME MEASURES: Comparison of seven different techniques, 20 nostrils and 140 endoscopic videos for the deposition patterns of dyed test formulation. Analysis was possible in 90% of all endoscopic videos. Three head positions were tested for both nasal drops and nasal sprays. RESULTS: Deposition of dyed test formulation near the middle meatus was observed in 43% of all observations. No significant differences were observed in terms of delivery between any of the seven techniques. CONCLUSIONS: Our study suggests there may not be a single 'best' technique for topical nasal drug delivery. A more individual approach to topical nasal drug treatment, taking anatomy and head position into account would seem to be more appropriate.
Authors: Sara Treat; Charles S Ebert; Zainab Farzal; Saikat Basu; Adam M Zanation; Brian D Thorp; Julia S Kimbell; Brent A Senior; Adam J Kimple Journal: Rhinol Online Date: 2020-11-08