OBJECTIVE: To develop a clinical practice guideline that provides recommendations for the fluid, i.e. colloid or crystalloid, used for resuscitation in critically ill neonates and children up to the age of 18 years with hypovolemia. METHODS: The guideline was developed through a comprehensive search and analysis of the pediatric literature. Recommendations were formulated by a national multidisciplinary committee involving all stakeholders in neonatal and pediatric intensive care and were based on research evidence from the literature and, in areas where the evidence was insufficient or lacking, on consensus after discussions in the committee. RESULTS: Because of the lack of evidence in neonates and children, trials conducted in adults were considered. We found several recent meta-analyses that show excess mortality in albumin-treated groups, compared with crystalloid-treated groups, and one recent large randomized controlled trial that found evidence of no mortality difference. We found no evidence that synthetic colloids are superior to crystalloid solutions. CONCLUSIONS: Given the state of the evidence and taking all other considerations into account, the guideline-developing group and the multidisciplinary committee recommend that in neonates and children with hypovolemia the first-choice fluid for resuscitation should be isotonic saline.
OBJECTIVE: To develop a clinical practice guideline that provides recommendations for the fluid, i.e. colloid or crystalloid, used for resuscitation in critically ill neonates and children up to the age of 18 years with hypovolemia. METHODS: The guideline was developed through a comprehensive search and analysis of the pediatric literature. Recommendations were formulated by a national multidisciplinary committee involving all stakeholders in neonatal and pediatric intensive care and were based on research evidence from the literature and, in areas where the evidence was insufficient or lacking, on consensus after discussions in the committee. RESULTS: Because of the lack of evidence in neonates and children, trials conducted in adults were considered. We found several recent meta-analyses that show excess mortality in albumin-treated groups, compared with crystalloid-treated groups, and one recent large randomized controlled trial that found evidence of no mortality difference. We found no evidence that synthetic colloids are superior to crystalloid solutions. CONCLUSIONS: Given the state of the evidence and taking all other considerations into account, the guideline-developing group and the multidisciplinary committee recommend that in neonates and children with hypovolemia the first-choice fluid for resuscitation should be isotonic saline.
Authors: Bridget A Wills; M Dung Nguyen; T Loan Ha; T H Tam Dong; T N Thuy Tran; T T Minh Le; V Diet Tran; T Hao Nguyen; V Chau Nguyen; Kasia Stepniewska; Nicholas J White; Jeremy J Farrar Journal: N Engl J Med Date: 2005-09-01 Impact factor: 91.245
Authors: B A Pockaj; J C Yang; M T Lotze; J R Lange; W F Spencer; S M Steinberg; S L Topalian; D J Schwartzentruber; D E White; S A Rosenberg Journal: J Immunother Emphasis Tumor Immunol Date: 1994-01
Authors: Peter Andrews; Elie Azoulay; Massimo Antonelli; Laurent Brochard; Christian Brun-Buisson; Daniel De Backer; Geoffrey Dobb; Jean-Yves Fagon; Herwig Gerlach; Johan Groeneveld; Duncan Macrae; Jordi Mancebo; Philipp Metnitz; Stefano Nava; Jerôme Pugin; Michael Pinsky; Peter Radermacher; Christian Richard Journal: Intensive Care Med Date: 2007-02-14 Impact factor: 17.440
Authors: Marissa Lipton; Ruchi Mahajan; Catherine Kavanagh; Carol Shen; Ibrahim Batal; Samriti Dogra; Namrata G Jain; Fangming Lin; Natalie S Uy Journal: Kidney360 Date: 2021-02-03
Authors: A S Fialho; L A Celi; F Cismondi; S M Vieira; S R Reti; J M C Sousa; S N Finkelstein Journal: Methods Inf Med Date: 2013-08-28 Impact factor: 2.176