PURPOSE: Case-control studies have reported inconsistent results concerning the association between polymorphisms in the androgen and estrogen receptor (ER) genes and breast cancer. While several studies investigated the association between the androgen receptor (AR) gene, CAG repeat and breast cancer, for the CA and TA repeats in the ER genes there are considerably fewer studies (one for CA and none for TA). METHODS: We have investigated the potential link between three tandem repeats (CAG, TA, and CA) in the AR, ERs alpha and beta genes, respectively, and breast cancer. DNA was isolated from 153 invasive breast tumors and 318 controls, and the three tandem repeats were sized by polyacrylamide electrophoresis. Number of repeats in each allele and the total repeats of both alleles were taken as variables for classification into dichotomous groups using the median of each variable in the control group as cut-off point. Relationship between polymorphic tandem repeats and breast cancer was assessed by multivariate logistic regression models. RESULTS: Three variables combined, longer CAGsum (> or =28), shorter TA (<23) and CA (<23) repeats could constitute a possible genetic profile associated with breast cancer. CONCLUSIONS: Our results confirm previous reports regarding an association between longer CAG repeats and breast cancer. In addition to that, we found that the combination of long CAG, short TA and CA repeats are strongly associated with breast cancer.
PURPOSE: Case-control studies have reported inconsistent results concerning the association between polymorphisms in the androgen and estrogen receptor (ER) genes and breast cancer. While several studies investigated the association between the androgen receptor (AR) gene, CAG repeat and breast cancer, for the CA and TA repeats in the ER genes there are considerably fewer studies (one for CA and none for TA). METHODS: We have investigated the potential link between three tandem repeats (CAG, TA, and CA) in the AR, ERs alpha and beta genes, respectively, and breast cancer. DNA was isolated from 153 invasive breast tumors and 318 controls, and the three tandem repeats were sized by polyacrylamide electrophoresis. Number of repeats in each allele and the total repeats of both alleles were taken as variables for classification into dichotomous groups using the median of each variable in the control group as cut-off point. Relationship between polymorphic tandem repeats and breast cancer was assessed by multivariate logistic regression models. RESULTS: Three variables combined, longer CAGsum (> or =28), shorter TA (<23) and CA (<23) repeats could constitute a possible genetic profile associated with breast cancer. CONCLUSIONS: Our results confirm previous reports regarding an association between longer CAG repeats and breast cancer. In addition to that, we found that the combination of long CAG, short TA and CA repeats are strongly associated with breast cancer.
Authors: C Menin; G L Banna; G De Salvo; V Lazzarotto; A De Nicolo; S Agata; M Montagna; G Sordi; O Nicoletto; L Chieco-Bianchi; E D'Andrea Journal: Cancer Lett Date: 2001-07-10 Impact factor: 8.679
Authors: Y A Elhaji; B Gottlieb; R Lumbroso; L K Beitel; W D Foulkes; L Pinsky; M A Trifiro Journal: Breast Cancer Res Treat Date: 2001-11 Impact factor: 4.872
Authors: Asta Försti; Chunyan Zhao; Elisabeth Israelsson; Karin Dahlman-Wright; Jan-Ake Gustafsson; Kari Hemminki Journal: Breast Cancer Res Treat Date: 2003-06 Impact factor: 4.872
Authors: F Berrino; P Muti; A Micheli; G Bolelli; V Krogh; R Sciajno; P Pisani; S Panico; G Secreto Journal: J Natl Cancer Inst Date: 1996-03-06 Impact factor: 13.506
Authors: L Kadouri; D F Easton; S Edwards; A Hubert; Z Kote-Jarai; B Glaser; F Durocher; D Abeliovich; T Peretz; R A Eeles Journal: Br J Cancer Date: 2001-07-06 Impact factor: 7.640
Authors: Lori C Sakoda; Christie R Blackston; Jennifer A Doherty; Roberta M Ray; Ming Gang Lin; Dao Li Gao; Helge Stalsberg; Ziding Feng; David B Thomas; Chu Chen Journal: Cancer Epidemiol Date: 2010-09-17 Impact factor: 2.984