Literature DB >> 16790025

Effect of the morphogene bolA on the permeability of the Escherichia coli outer membrane.

Patrick Freire1, Helena L A Vieira, Ana R Furtado, Miguel A de Pedro, Cecília M Arraiano.   

Abstract

Escherichia coli bolA is a morphogene involved in stress response and cell division. Overexpression of bolA induces biofilm formation and affects the levels of carboxypeptidases PBP5, PBP6 and beta-lactamase AmpC. In this study, we have shown that changes in the expression of bolA result in alterations in the properties of the outer membrane. The sensitivity to detergents and vancomycin was reduced when bolA was overexpressed and fluorescent probes indicated that different levels of bolA had an effect on outer membrane protein accessibility. Moreover, bolA was shown to be involved in the modulation of the OmpF/OmpC balance.

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Year:  2006        PMID: 16790025     DOI: 10.1111/j.1574-6968.2006.00307.x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN: 0378-1097            Impact factor:   2.742


  17 in total

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