Literature DB >> 16789732

Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): an antiapoptotic polymeric nanomedicine.

María J Vicent1, Enrique Pérez-Payá.   

Abstract

An antiapoptotic polymeric nanomedicine, PGA-peptoid 1, has been developed by the conjugation of a novel apoptotic protease activating factor 1 (Apaf-1) inhibitor (peptoid 1) to poly-L-glutamic acid (PGA). Full structural and biophysical characterization of the conjugate by different techniques has been accomplished. This macromolecule clearly enhances the antiapoptotic activity of peptoid 1 in different cell models.

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Year:  2006        PMID： 16789732     DOI： 10.1021/jm060458x

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  8 in total

1.  Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions.

Authors:  Yadira Palacios-Rodríguez; Guillermo García-Laínez; Mónica Sancho; Anna Gortat; Mar Orzáez; Enrique Pérez-Payá
Journal:  J Biol Chem       Date:  2011-11-07       Impact factor: 5.157

Review 2.  Polymer-drug conjugates as modulators of cellular apoptosis.

Authors:  María J Vicent
Journal:  AAPS J       Date:  2007-06-15       Impact factor: 4.009

3.  Integrin-assisted drug delivery of nano-scaled polymer therapeutics bearing paclitaxel.

Authors:  Anat Eldar-Boock; Keren Miller; Joaquin Sanchis; Ruth Lupu; María J Vicent; Ronit Satchi-Fainaro
Journal:  Biomaterials       Date:  2011-03-04       Impact factor: 12.479

4.  A systems biology analysis of apoptosome formation and apoptosis execution supports allosteric procaspase-9 activation.

Authors:  Maximilian L Würstle; Markus Rehm
Journal:  J Biol Chem       Date:  2014-08-08       Impact factor: 5.157

5.  Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease.

Authors:  Marcello D'Amelio; Virve Cavallucci; Silvia Middei; Cristina Marchetti; Simone Pacioni; Alberto Ferri; Adamo Diamantini; Daniela De Zio; Paolo Carrara; Luca Battistini; Sandra Moreno; Alberto Bacci; Martine Ammassari-Teule; Hélène Marie; Francesco Cecconi
Journal:  Nat Neurosci       Date:  2010-12-12       Impact factor: 24.884

Review 6.  Solid-phase synthesis of N-substituted glycine oligomers (alpha-peptoids) and derivatives.

Authors:  Adrian S Culf; Rodney J Ouellette
Journal:  Molecules       Date:  2010-08-04       Impact factor: 4.411

7.  A polymeric nanomedicine diminishes inflammatory events in renal tubular cells.

Authors:  Alvaro C Ucero; Sergio Berzal; Carlos Ocaña-Salceda; Mónica Sancho; Mar Orzáez; Angel Messeguer; Marta Ruiz-Ortega; Jesús Egido; María J Vicent; Alberto Ortiz; Adrián M Ramos
Journal:  PLoS One       Date:  2013-01-02       Impact factor: 3.240

8.  A nanoconjugate Apaf-1 inhibitor protects mesothelial cells from cytokine-induced injury.

Authors:  Beatriz Santamaría; Alberto Benito-Martin; Alvaro Conrado Ucero; Luiz Stark Aroeira; Ana Reyero; María Jesús Vicent; Mar Orzáez; Angel Celdrán; Jaime Esteban; Rafael Selgas; Marta Ruíz-Ortega; Manuel López Cabrera; Jesús Egido; Enrique Pérez-Payá; Alberto Ortiz
Journal:  PLoS One       Date:  2009-08-13       Impact factor: 3.240
  8 in total

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