Literature DB >> 16789721

Alpha-fetoprotein in serum and tumor tissues in dogs with hepatocellular carcinoma.

Satoshi Kitao1, Takatsugu Yamada, Takefumi Ishikawa, Hiroo Madarame, Mitsuru Furuichi, Sakurako Neo, Ryo Tsuchiya, Kosaku Kobayashi.   

Abstract

Serum alpha-fetoprotein (AFP) concentrations were measured before and after surgical removal of tumor masses in four dogs with hepatocellular carcinoma (HCC). Localization of AFP was also examined immunohistochemically in tumor tissues. In three cases, the serum AFP concentration was 10 to 20 times higher than that of normal dogs. One to two months after surgery, the serum AFP concentration had decreased to normal range. AFP was localized in the tumor tissues in these three cases. One case, which had a low serum AFP, did not show AFP localization in tumor tissue.

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Year:  2006        PMID： 16789721     DOI： 10.1177/104063870601800312

Source DB:  PubMed          Journal:  J Vet Diagn Invest        ISSN： 1040-6387            Impact factor:   1.279


  3 in total

1.  Hepatocellular carcinoma in a young dog.

Authors:  Takahiro Teshima; Hirotaka Matsumoto; Kae Shigihara; Harumi Sawada; Masaki Michishita; Kimimasa Takahashi; Hidekazu Koyama
Journal:  Can Vet J       Date:  2013-09       Impact factor: 1.008

2.  Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours.

Authors:  Renee G H M van Sprundel; Ted S G A M van den Ingh; Valeer J Desmet; Azeam Katoonizadeh; Louis C Penning; Jan Rothuizen; Tania Roskams; Bart Spee
Journal:  Comp Hepatol       Date:  2010-02-18

3.  A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells.

Authors:  Giang N Nguyen; John K Everett; Samita Kafle; Aoife M Roche; Hayley E Raymond; Jacob Leiby; Christian Wood; Charles-Antoine Assenmacher; Elizabeth P Merricks; C Tyler Long; Haig H Kazazian; Timothy C Nichols; Frederic D Bushman; Denise E Sabatino
Journal:  Nat Biotechnol       Date:  2020-11-16       Impact factor: 54.908
  3 in total

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