OBJECTIVE: To investigate the risk factors associated with nosocomial acquisition of imipenem-resistant Acinetobacter baumannii (IRAB) among pediatric intensive care patients. A retrospective case control study was conducted in a pediatric intensive care unit (PICU). PATIENTS AND PARTICIPANTS: Cases were children in whom IRAB was isolated from any clinical specimen obtained at least 48 h following admission to PICU. Controls were children without IRAB matched to cases in 2:1 ratio. Twenty-six cases were matched with 52 controls according to the chronological order of admission. MEASUREMENTS AND RESULTS: Between July 2001 and December 2003, 52 (62%) of 84 clinical A. baumannii isolates were found nonsusceptible to imipenem (MIC > or = 8 microg/ml). Demographic variables, comorbid conditions, clinical picture at admission, invasive procedures, use of antimicrobials and other drugs were analyzed as potential risk factors. Use of carbapenems and other beta-lactams, aminoglycosides, ranitidine, mechanical ventilation, central venous or urinary catheters and length of stay in PICU were among the factors significantly associated with IRAB acquisition in the univariate analysis. By multivariate analysis, however, only aminoglycoside use and length of stay in the PICU were independent risk factors. CONCLUSIONS: Acquisition of IRAB by PICU patients was independently associated with aminoglycoside use and prolonged stay in the unit. Studies of evaluation of infection control policies need to be pursued.
OBJECTIVE: To investigate the risk factors associated with nosocomial acquisition of imipenem-resistant Acinetobacter baumannii (IRAB) among pediatric intensive care patients. A retrospective case control study was conducted in a pediatric intensive care unit (PICU). PATIENTS AND PARTICIPANTS: Cases were children in whom IRAB was isolated from any clinical specimen obtained at least 48 h following admission to PICU. Controls were children without IRAB matched to cases in 2:1 ratio. Twenty-six cases were matched with 52 controls according to the chronological order of admission. MEASUREMENTS AND RESULTS: Between July 2001 and December 2003, 52 (62%) of 84 clinical A. baumannii isolates were found nonsusceptible to imipenem (MIC > or = 8 microg/ml). Demographic variables, comorbid conditions, clinical picture at admission, invasive procedures, use of antimicrobials and other drugs were analyzed as potential risk factors. Use of carbapenems and other beta-lactams, aminoglycosides, ranitidine, mechanical ventilation, central venous or urinary catheters and length of stay in PICU were among the factors significantly associated with IRAB acquisition in the univariate analysis. By multivariate analysis, however, only aminoglycoside use and length of stay in the PICU were independent risk factors. CONCLUSIONS: Acquisition of IRAB by PICU patients was independently associated with aminoglycoside use and prolonged stay in the unit. Studies of evaluation of infection control policies need to be pursued.
Authors: M del Mar Tomas; M Cartelle; S Pertega; A Beceiro; P Llinares; D Canle; F Molina; R Villanueva; J M Cisneros; G Bou Journal: Clin Microbiol Infect Date: 2005-07 Impact factor: 8.067
Authors: B Mulin; D Talon; J F Viel; C Vincent; R Leprat; M Thouverez; Y Michel-Briand Journal: Eur J Clin Microbiol Infect Dis Date: 1995-07 Impact factor: 3.267
Authors: Andrew E Simor; Mark Lee; Mary Vearncombe; Linda Jones-Paul; Clare Barry; Manuel Gomez; Joel S Fish; Robert C Cartotto; Robert Palmer; Marie Louie Journal: Infect Control Hosp Epidemiol Date: 2002-05 Impact factor: 3.254
Authors: Felipe Fernández-Cuenca; Luis Martínez-Martínez; Maria Carmen Conejo; Juan A Ayala; Evelio J Perea; Alvaro Pascual Journal: J Antimicrob Chemother Date: 2003-03 Impact factor: 5.790
Authors: J L Vincent; D J Bihari; P M Suter; H A Bruining; J White; M H Nicolas-Chanoin; M Wolff; R C Spencer; M Hemmer Journal: JAMA Date: 1995 Aug 23-30 Impact factor: 56.272
Authors: Pilar Villalón; Sylvia Valdezate; Maria J Medina-Pascual; Virginia Rubio; Ana Vindel; Juan A Saez-Nieto Journal: J Clin Microbiol Date: 2010-12-22 Impact factor: 5.948
Authors: Peter Andrews; Elie Azoulay; Massimo Antonelli; Laurent Brochard; Christian Brun-Buisson; Daniel De Backer; Geoffrey Dobb; Jean-Yves Fagon; Herwig Gerlach; Johan Groeneveld; Duncan Macrae; Jordi Mancebo; Philipp Metnitz; Stefano Nava; Jerôme Pugin; Michael Pinsky; Peter Radermacher; Christian Richard Journal: Intensive Care Med Date: 2007-02-14 Impact factor: 17.440
Authors: H H Balkhy; M S Bawazeer; R F Kattan; H M Tamim; S M Al Johani; F A Aldughashem; H A Al Alem; A Adlan; L A Herwaldt Journal: Eur J Clin Microbiol Infect Dis Date: 2012-04-05 Impact factor: 3.267
Authors: C Routsi; M Pratikaki; E Platsouka; C Sotiropoulou; S Nanas; V Markaki; C Vrettou; O Paniara; H Giamarellou; C Roussos Journal: Infection Date: 2010-03-12 Impact factor: 3.553