Literature DB >> 16788391

Effects of botulinum toxin-A on gait velocity, step length, and base of support of patients with dynamic equinovarus foot.

Matteo Cioni1, Alberto Esquenazi, Barbara Hirai.   

Abstract

OBJECTIVE: The aim of this study was to identify if botulinum toxin type A is a drug able to modify walking velocity, step length, and width of the base of support of adult patients with dynamic equinovarus foot deformity resulting from upper motor neuron syndrome.
DESIGN: This retrospective study analyzed data from 20 patients' files selected from 448 consecutive charts. The main inclusion criteria were the presence of dynamic equinovarus foot deformity due to upper motor neuron syndrome, age between 20 and 80 yrs, evaluation of temporospatial parameters of gait by the Gait Mat II before and 4 wks after botulinum toxin type A injection to the calf muscles, and the ability to walk barefoot, unassisted, and without braces. For data analysis, based on walking velocity, we divided the patients into two groups, slow walking velocity (0.18-0.49 m/sec) and medium walking velocity (0.50-0.99 m/sec).
RESULTS: Width of the base of support was significantly reduced after botulinum toxin type A treatment, both for the affected (P < 0.005) and the unaffected limbs (P < 0.002), in the group of subjects walking at medium velocity. Walking velocity or step length of either group of patients was not significantly modified by botulinum toxin type A treatment.
CONCLUSIONS: Based on this study, a significant effect of botulinum toxin type A on width of the base of support is evident and seems to be the result of a better position of the affected foot during the stance phase of locomotion leading to increased body stability and consequent reduction of width of the base of support of the unaffected limb. No change was evident in step length or walking velocity for this patient population.

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Year:  2006        PMID: 16788391     DOI: 10.1097/01.phm.0000223216.50068.bc

Source DB:  PubMed          Journal:  Am J Phys Med Rehabil        ISSN: 0894-9115            Impact factor:   2.159


  9 in total

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Authors:  Pierre Burbaud; Camille Ducerf; Emmanuelle Cugy; Jean-Louis Dubos; François Muller; Dominique Guehl; Patrick Dehail; Didier Cugy; Nicholas Moore; Alain Lagueny; Pierre-Alain Joseph
Journal:  J Neurol       Date:  2011-03-20       Impact factor: 4.849

2.  Botulinum Toxin Type A Improves Function According to Goal Attainment in Adults with Poststroke Lower Limb Spasticity in Real Life Practice.

Authors:  Lourdes López de Munain; Josep Valls-Solé; Irene Garcia Pascual; Pascal Maisonobe
Journal:  Eur Neurol       Date:  2019-11-14       Impact factor: 1.710

3.  Factors Influencing Gait Velocity Improvement Following Botulinum Toxin Injection for Spasticity of the Plantar Flexors in Patients with Stroke.

Authors:  Kazuki Fujita; Yasutaka Kobayashi; Masahito Hitosugi; Tomomi Nomura; Tomoko Nishida; Yuichi Tsushima; Tomoki Ogawa; Hirotaka Kinoshita; Hideaki Hori
Journal:  Prog Rehabil Med       Date:  2020-10-07

4.  Combined Effects of Isokinetic Training and Botulinum Toxin Type A on Spastic Equinus Foot in Patients with Chronic Stroke: A Pilot, Single-blind, Randomized Controlled Trial.

Authors:  Nicoletta Cinone; Sara Letizia; Luigi Santoro; Salvatore Facciorusso; Raffaella Armiento; Alessandro Picelli; Maurizio Ranieri; Andrea Santamato
Journal:  Toxins (Basel)       Date:  2019-04-08       Impact factor: 4.546

5.  Ankle and Foot Spasticity Patterns in Chronic Stroke Survivors with Abnormal Gait.

Authors:  Sheng Li
Journal:  Toxins (Basel)       Date:  2020-10-07       Impact factor: 4.546

6.  Ultrasonographic Evaluation of Three Approaches for Botulinum Toxin Injection into Tibialis Posterior Muscle in Chronic Stroke Patients with Equinovarus Foot: An Observational Study.

Authors:  Stefania Spina; Salvatore Facciorusso; Chiara Botticelli; Domenico Intiso; Maurizio Ranieri; Antonio Colamaria; Pietro Fiore; Chiara Ciritella; François Genêt; Andrea Santamato
Journal:  Toxins (Basel)       Date:  2021-11-22       Impact factor: 4.546

7.  Functional influence of botulinum neurotoxin type A treatment (Xeomin®) of multifocal upper and lower limb spasticity on chronic hemiparetic gait.

Authors:  Maurizio Falso; Rosalba Galluso; Andrea Malvicini
Journal:  Neurol Int       Date:  2012-05-29

8.  Role of ankle foot orthosis in improving locomotion and functional recovery in patients with stroke: A prospective rehabilitation study.

Authors:  H Sankaranarayan; Anupam Gupta; Meeka Khanna; Arun B Taly; K Thennarasu
Journal:  J Neurosci Rural Pract       Date:  2016 Oct-Dec

9.  BoNT-A for Post-Stroke Spasticity: Guidance on Unmet Clinical Needs from a Delphi Panel Approach.

Authors:  Alessio Baricich; Theodore Wein; Nicoletta Cinone; Michele Bertoni; Alessandro Picelli; Carmelo Chisari; Franco Molteni; Andrea Santamato
Journal:  Toxins (Basel)       Date:  2021-03-25       Impact factor: 4.546

  9 in total

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