| Literature DB >> 16787760 |
G García1, M Arango, A B Pérez, L Fonte, B Sierra, R Rodríguez-Roche, E Aguirre, I Fiterre, M G Guzmán.
Abstract
Acute and late convalescent sera (collected at day 5 of disease onset and 1 year later) from dengue fever (DF) and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) laboratory confirmed cases, were tested for antibody-dependent cell-mediated cytotoxicity (ADCC) activity using dengue 1 (DENV-1) or dengue 2 (DENV-2) infected cells as target. All patients experienced their first dengue virus (DENV) infection 20 years before. ADCC activity was detected in acute sera from DHF/DSS but not in sera from DF patients. However, 1 year after illness, ADCC activity was observed in all cases. This preliminary report represents one of the few studies of ADCC in dengue patients and suggests that ADCC could be implicated in dengue pathogenesis.Entities:
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Year: 2006 PMID： 16787760 DOI： 10.1016/j.jcv.2006.04.010
Source DB: PubMed Journal: J Clin Virol ISSN： 1386-6532 Impact factor: 3.168