| Literature DB >> 16787636 |
Adam Szewczyk1, Jolanta Skalska, Marta Głab, Bogusz Kulawiak, Dominika Malińska, Izabela Koszela-Piotrowska, Wolfram S Kunz.
Abstract
Mitochondrial potassium channels, such as ATP-regulated or large conductance Ca2+ -activated and voltage gated channels were implicated in cytoprotective phenomenon in different tissues. Basic effects of these channels activity include changes in mitochondrial matrix volume, mitochondrial respiration and membrane potential, and generation of reactive oxygen species. In this paper, we describe the pharmacological properties of mitochondrial potassium channels and their modulation by channel inhibitors and potassium channel openers. We also discuss potential side effects of these substances.Entities:
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Year: 2006 PMID： 16787636 DOI： 10.1016/j.bbabio.2006.05.002
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002