Literature DB >> 16787381

Ceramide involvement in apoptosis and apoptotic diseases.

Karin Thevissen1, Isabelle E J A François, Joris Winderickx, Christophe Pannecouque, Bruno P A Cammue.   

Abstract

Apoptosis is implicated in a number of diseases, including neurodegenerative diseases and AIDS. More and more, evidence is accumulating pointing to the critical role of ceramides in the induction of apoptosis. The present review summarizes (i) the molecular basis and regulation of the apoptotic machinery, (ii) the molecular role of ceramides in the induction or execution of apoptotic pathways, and (iii) evidence linking ceramide generation to various apoptotic diseases. Additionally, this review discusses putative therapeutic approaches inhibiting ceramide production in apoptotic diseases.

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Year:  2006        PMID： 16787381     DOI： 10.2174/138955706777435643

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  22 in total

Review 1.  Nuclear sphingolipid metabolism.

Authors:  Natasha C Lucki; Marion B Sewer
Journal:  Annu Rev Physiol       Date:  2011-09-09       Impact factor: 19.318

2.  The plant decapeptide OSIP108 prevents copper-induced apoptosis in yeast and human cells.

Authors:  Pieter Spincemaille; Gursimran Chandhok; Benjamin Newcomb; Jef Verbeek; Kim Vriens; Andree Zibert; Hartmut Schmidt; Yusuf A Hannun; Jos van Pelt; David Cassiman; Bruno P A Cammue; Karin Thevissen
Journal:  Biochim Biophys Acta       Date:  2014-03-13

3.  Antifungal activity of PvD1 defensin involves plasma membrane permeabilization, inhibition of medium acidification, and induction of ROS in fungi cells.

Authors:  Erica O Mello; Suzanna F F Ribeiro; André O Carvalho; Izabela S Santos; Maura Da Cunha; Claudete Santa-Catarina; Valdirene M Gomes
Journal:  Curr Microbiol       Date:  2010-12-19       Impact factor: 2.188

Review 4.  A role for sphingolipids in the pathophysiology of obesity-induced inflammation.

Authors:  Benjamin T Bikman
Journal:  Cell Mol Life Sci       Date:  2012-07       Impact factor: 9.261

5.  Inhibition of CFTR Cl- channel function caused by enzymatic hydrolysis of sphingomyelin.

Authors:  Yajamana Ramu; Yanping Xu; Zhe Lu
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-30       Impact factor: 11.205

6.  Phosphatidylinositol 3-kinase inhibitor (PIK75) containing surface functionalized nanoemulsion for enhanced drug delivery, cytotoxicity and pro-apoptotic activity in ovarian cancer cells.

Authors:  Meghna Talekar; Srinivas Ganta; Amit Singh; Mansoor Amiji; Jackie Kendall; William A Denny; Sanjay Garg
Journal:  Pharm Res       Date:  2012-06-01       Impact factor: 4.200

Review 7.  The interplay between bioactive sphingolipids and steroid hormones.

Authors:  Natasha C Lucki; Marion B Sewer
Journal:  Steroids       Date:  2010-02-04       Impact factor: 2.668

Review 8.  Converging roles for sphingolipids and cell stress in the progression of neuro-AIDS.

Authors:  Norman J Haughey; Joesph Steiner; Avindra Nath; Justin C McArthur; Ned Sacktor; Carlos Pardo; Veera Venkata Ratnam Bandaru
Journal:  Front Biosci       Date:  2008-05-01

9.  FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells.

Authors:  Evgeny V Berdyshev; Irina Gorshkova; Anastasia Skobeleva; Robert Bittman; Xuequan Lu; Steven M Dudek; Tamara Mirzapoiazova; Joe G N Garcia; Viswanathan Natarajan
Journal:  J Biol Chem       Date:  2009-01-01       Impact factor: 5.157

10.  A Nonradioactive Fluorimetric SPE-Based Ceramide Kinase Assay Using NBD-C(6)-Ceramide.

Authors:  Helena Van Overloop; Gerd Van der Hoeven; Paul P Van Veldhoven
Journal:  J Lipids       Date:  2012-07-26
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