| Literature DB >> 16786080 |
Stephen G Davies1, A Christopher Garner, Euan C Goddard, Dennis Kruchinin, Paul M Roberts, Humberto Rodriguez-Solla, Andrew D Smith.
Abstract
Conjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino)but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. and > 98% e.e.Entities:
Year: 2006 PMID： 16786080 DOI： 10.1039/b604835h
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222