| Literature DB >> 16784901 |
Shyam Unniraman1, David G Schatz.
Abstract
Chromosomal translocations involving Ig heavy chain switch regions and an oncogene, like Myc, represent early initiating events in the development of many B cell malignancies. These translocations are widely believed to result from aberrant class switch recombination (CSR). Recent reports have produced conflicting models for the role of activation-induced cytidine deaminase (AID) in this process. Here, we discuss possible roles of AID, CSR, and somatic hypermutation in generating chromosomal translocations and in tumor progression.Entities:
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Year: 2006 PMID： 16784901 DOI： 10.1016/j.dnarep.2006.05.019
Source DB: PubMed Journal: DNA Repair (Amst) ISSN： 1568-7856