| Literature DB >> 16784890 |
J Santiago Mejia1, Jeanette V Bishop, Richard G Titus.
Abstract
Hematophagous arthropods that transmit the etiological agents of arthropod-borne diseases have become the focus of anti-vector vaccines, targeted mainly at components of their saliva and midgut. These efforts have been directed mostly towards developing species-specific vaccines. An alternative is to target cross-reactive epitopes that have been preserved during evolution of the arthropods. The N- and O-linked glycans that are attached to arthropod glycoproteins are one of the potential targets of this pan-arthropod vaccine approach. Here, we discuss how genetically modified Drosophila melanogaster cells can be used to synthesize and to deliver these arthropod glycans to vertebrate hosts.Entities:
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Year: 2006 PMID： 16784890 DOI： 10.1016/j.pt.2006.06.001
Source DB: PubMed Journal: Trends Parasitol ISSN： 1471-4922