| Literature DB >> 16784850 |
Aloysius T Nchinda1, Kelly Chibale, Pierre Redelinghuys, Edward D Sturrock.
Abstract
Novel analogues of the angiotensin I-converting enzyme (ACE) inhibitor keto-ACE were synthesized via a facile Horner-Emmons olefination of a phosphonoketone precursor with ethyl glyoxylate. Introduction of a bulky aromatic tryptophan at the P(2)(') position of keto-ACE resulted in a significant increase in C-domain-selectivity.Entities:
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Year: 2006 PMID： 16784850 DOI： 10.1016/j.bmcl.2006.06.003
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823