| Literature DB >> 16784845 |
Xiaodong Lin1, Alice C Rico, Daniel T Chu, Georgia L Carroll, Lynn Barker, Ribhi Shawar, Manoj C Desai, Jacob J Plattner.
Abstract
Synthesis of C(12) des-methyl ketolide is developed featuring an intramolecular epoxide formation/elimination process to establish the C(12) stereocenter. These ketolides are potent against several key respiratory pathogens, including erythromycin resistant erm- and mef-containing strains of Streptococcus pneumoniae.Entities:
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Year: 2006 PMID： 16784845 DOI： 10.1016/j.bmcl.2006.05.104
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823