| Literature DB >> 16784844 |
Alexey Rivkin1, Yoona R Kim, Mark T Goulet, Nathan Bays, Armetta D Hill, Ilona Kariv, Stefan Krauss, Nicole Ginanni, Peter R Strack, Nancy E Kohl, Christine C Chung, Jeffrey P Varnerin, Paul N Goudreau, Amy Chang, Michael R Tota, Benito Munoz.
Abstract
A series of 3-aryl-4-hydroxyquinolin-2(1H)-ones with fatty acid synthase inhibitory activity was prepared. Starting from a derivative with an IC(50) = 1.4 microM, SAR studies led to compounds with more than 70-fold increase in potency (IC(50) < 20 nM).Entities:
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Year: 2006 PMID： 16784844 DOI： 10.1016/j.bmcl.2006.06.014
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823