Literature DB >> 16784842

Synthesis and evaluation of phenoxy acetic acid derivatives as [corrected] anti-mycobacterial agents.

Mohammad Shaharyar1, Mohammad Shahar yar, Anees Ahmad Siddiqui, Mohamed Ashraf Ali.   

Abstract

In present investigation, 2-(4-formyl-2-methoxyphenoxy) acetic acid on condensation with various ketones in methanolic KOH solution yielded the corresponding chalcones (1-3). These corresponding chalcones were reacted with appropriate acid hydrazide in glacial acetic acid led to the formation of phenoxy acetic acid derivatives. All newly synthesized compounds were evaluated for their anti-mycobacterial activities against Mycobacterium tuberculosis H(37)Rv.

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Year:  2006        PMID: 16784842     DOI: 10.1016/j.bmcl.2006.06.021

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  4 in total

1.  3,5-Bis[1-acetyl-5-(4-chloro-phen-yl)-4,5-dihydro-1H-pyrazol-3-yl]-2,6-dimethyl-pyridine.

Authors:  Qun Qian; Jun Zhang; Min Zhang; Xiang He; Yi-Ben Xia
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-08-06

2.  5-(Anthracen-9-yl)-3-(4-nitro-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazole.

Authors:  Bao-Li Dong; Ming-Liang Wang; Yong-Hua Li
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-10-09

3.  1-(4-Methyl-phenyl-sulfon-yl)-5-phenyl-4,5-dihydro-1H-pyrazole.

Authors:  Jie Li; Wei Zhao
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-07-02

4.  Synthesis and anti-bacterial activities of a bis-chalcone derived from thiophene and its bis-cyclized products.

Authors:  Abdullah M Asiri; Salman A Khan
Journal:  Molecules       Date:  2011-01-12       Impact factor: 4.411

  4 in total

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